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May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis.
|Sequence:||3; NC_000003.12 (45082277..45146422, complement)|
Highly expressed in mitotic cells with low expression during interphase. Detected at highest levels in skeletal muscle and colon with lower levels in kidney, small intestine, placenta and lung. Up-regulated in a number of human tumor cell lines, as well as in colorectal cancer, breast carcinoma and lung cancer. Also expressed in cells with phenotypes reminiscent of mesenchymal stem cells and neural stem cells.
[Isoform 1]: Cell membrane; Single-pass membrane protein. Shedding may also lead to a soluble peptide.; [Isoform 3]: Secreted.