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- Table of Contents
Facts about Cyclin-dependent kinase 3.
Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation.
Human | |
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Gene Name: | CDK3 |
Uniprot: | Q00526 |
Entrez: | 1018 |
Belongs to: |
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protein kinase superfamily |
Cell division protein kinase 3; cyclin-dependent kinase 3; EC 2.7.11; EC 2.7.11.22
Mass (kDA):
35.046 kDA
Human | |
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Location: | 17q25.1 |
Sequence: | 17; NC_000017.11 (76000906..76005999) |
Expressed in cancer cell lines and glioblastoma tissue.
PMID: 1639063 by Meyerson M., et al. A family of human cdc2-related protein kinases.
PMID: 8846921 by Hofmann F., et al. Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit.