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- Table of Contents
4 Citations 6 Q&As
4 Citations 1 Q&As
9 Citations
Facts about Cyclin-dependent kinase inhibitor 1.
Functions at the nuclear localization and assembly of cyclin D-CDK4 complex and boosts its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.
Human | |
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Gene Name: | CDKN1A |
Uniprot: | P38936 |
Entrez: | 1026 |
Belongs to: |
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CDI family |
CAP20cyclin-dependent kinase inhibitor 1; CDK-interacting protein 1; CDKN1A; CDKN1melanoma differentiation associated protein 6; CIP1; CIP1WAF1CDK-interaction protein 1; cyclin-dependent kinase inhibitor 1A (p21, Cip1); MDA6; MDA-6; Melanoma differentiation-associated protein 6; p21; p21CIP1; p21Cip1/Waf1; PIC1; SDI1DNA synthesis inhibitor; wild-type p53-activated fragment 1
Mass (kDA):
18.119 kDA
Human | |
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Location: | 6p21.2 |
Sequence: | 6; NC_000006.12 (36676463..36687332) |
Expressed in all adult tissues, with 5-fold lower levels observed in the brain.
Cytoplasm. Nucleus.
Boster Bio offers high-affinity primary antibodies that are specific against CDKN1A. These antibodies are highly cited and have been validated for use in Western Blotting, Immunohistochemistry, and ELISA. Read on for more details on Boster's CDKN1A products and research. This article also reviews Boster’s research in the other areas of protein.
If you are looking for a high-affinity CDKN1A antibody, Boster Bio has a product for you. Boster primary antibodies have been validated for use in Western Blotting, Immunohistochemistry, and ELISA. In addition, they are highly effective in inducing protein synthesis in various cells and tissues. These antibodies can be used by researchers around the globe.
The researchers examined the role played by the CDKN1A genetic mutation in the progression to cancer. They identified GCDs that had a phosphorylated CDKN1A genome. Atg5KO mice exhibited a majority of GCDs stained by CDKN1A/p21 on day 7. The expression of SA was lower than that in Atg5WT.
PMID: 8242751 by Harper J.W., et al. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
PMID: 8242752 by El-Deiry W.S., et al. WAF1, a potential mediator of p53 tumor suppression.
*More publications can be found for each product on its corresponding product page