Carboxylesterase 3 Antibodies

AND CES3 ELISA kits, Carboxylesterase 3 Proteins

Many biological assays use antibodies to detect Carboxylesterase 3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Carboxylesterase 3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Carboxylesterase 3 antibodies...

We validate the specificity of these antibodies to Carboxylesterase 3 by testing them on tissues known to express CES3 positively and negatively. Browse below to find the CES3 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CES3 Infographic by Boster Bio

All CES3 Products

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Specificity

Applications

Price

Anti-Carboxylesterase 3 CES3 Antibody

Western blot analysis of extracts of various cell lines, using CES3 antibody at 1:3000 dilution

Human, Mouse, Rat

$405
Cat # A07756
100ul

CES3 (NM_024922) Human Over-expression Lysate

Human

$960
Cat # LS023491
20 µg, 100 µg

CES3 Overview

Facts about Carboxylesterase 3.

CES3 3D structure. Source: alphafold

Carboxylesterase 3 (CES3)

Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)- 1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics.

Gene Information

Human
Gene Name:	CES3
Uniprot:	Q6UWW8
Entrez:	23491

Family

Belongs to:

type-B carboxylesterase/lipase family

Alternative Names

carboxylesterase 3 (brain); Carboxylesterase 3; CES3; EC 3.1.1; EC 3.1.1.1; ES31FLJ21736; esterase 31; Liver carboxylesterase 31 homolog

Molecular Weight

Mass (kDA):
62.282 kDA

Genomic Context


Human

Location:	16q22.1
Sequence:	16; NC_000016.10 (66961266..66975149)

Tissue Specificity

Expressed in liver, colon and small intestine.

Subcellular Localizations

Endoplasmic reticulum lumen.

Diseases

Steatohepatitis
Insulin Sensitivity
Malignant Tumor Of Colon
Cardiac Complication
Insulin Resistance
Malignant Neoplasms
Atherosclerosis
Diabetes Mellitus
Steatosis
Dyslipidemias
Colonic Neoplasms
Coronary Artery Disease

Macular Corneal Dystrophy Type I
Diabetic Angiopathies
Neoplasms
Diarrhea
Colorectal Cancer
Impaired Glucose Tolerance
Fatty Liver

Pathways

Secretion
Glucose Homeostasis
Nuclear Division
Rna Capping
Insulin Secretion
Cell Growth
Fatty Acid Oxidation

Localization
Organelle Localization

PTMs

Oxidation

Reduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CES3

References

PMID: 14581373 by Sanghani S.P., et al. Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis.

PMID: 15687373 by Quinney S.K., et al. Hydrolysis of capecitabine to 5'-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide.