Chac1 Antibodies

AND Chac1 ELISA kits, Chac1 Proteins

Many biological assays use antibodies to detect Chac1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Chac1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Chac1 antibodies...

We validate the specificity of these antibodies to Chac1 by testing them on tissues known to express Chac1 positively and negatively. Browse below to find the Chac1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Chac1 Infographic by Boster Bio

All Chac1 Products

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Product

Figures

Specificity

Applications

Price

CHAC1 (NM_001142776) Human Recombinant Protein

Coomassie blue staining of purified CHAC1 protein

$1249
Cat # PROTQ9BUX1
20 µg

Anti-CHAC1 Mouse Monoclonal Antibody [Clone ID: OTI1E2]

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CHAC1 (Right lane) cDNA for 48 hrs and lysed

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-CHAC1 mouse monoclonal antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human pancreas tissue using anti-CHAC1 mouse monoclonal antibody

Human, Mouse, Rat

IF, IHC, WB

$523
Cat # M09017
100 µl

CHAC1 (NM_024111) Human Over-expression Lysate

CHAC1 Human Over-expression Lysates NM_024111

Human

$628
Cat # LS079094
20 µg, 100 µg

Anti-CHAC1 Antibody Picoband®

Western blot analysis of CHAC1 using anti-CHAC1 antibody (A09017-2)

IHC analysis of CHAC1 using anti-CHAC1 antibody (A09017-2)

Human, Mouse, Rat

ELISA, IHC, WB

$370
Cat # A09017-2
100 μg/vial

Chac1 Overview

Facts about Glutathione-specific gamma-glutamylcyclotransferase 1.

Glutathione-specific gamma-glutamylcyclotransferase 1 (Chac1)

Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts especially on glutathione, but not on other gamma-glutamyl peptides.

Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic part of the unfolded protein response pathway by mediating the pro-apoptotic impacts of the ATF4-ATF3- DDIT3/CHOP cascade (By similarity).

Gene Information

Mouse
Gene Name:	Chac1
Uniprot:	Q8R3J5
Entrez:	69065

Family

Belongs to:

gamma-glutamylcyclotransferase family

Alternative Names

cation transport regulator-like protein 1; ChaC, cation transport regulator homolog 1 (E. coli)

Molecular Weight

Mass (kDA):
24.547 kDA

Genomic Context


Mouse

Location:	2\|2 E5
Sequence:	2;

Tissue Specificity

Widely expressed, with high expression in forebrain and anterior spinal cord. Expressed at intermediate level in the dorsal aorta and heart. Present throughout adult brain (at protein level).

Diseases

Malignant Neoplasm Of Breast
Endoplasmic Reticulum Stress
Malignant Neoplasms
Liver Diseases
Atherosclerosis
Physiological Stress
Alcoholic Liver Diseases
Neoplasms
Mammary Neoplasms

Malignant Neoplasm Of Ovary
Inflammation
Ovarian Neoplasm

Pathways

Transport
Cation Transport
Cell Death
Cell Proliferation
Cell Migration
Translation
Gene Silencing
Cell Cycle
Regulation Of Signaling

Negative Regulation Of Signaling
Chromatin Modification
Autophagy

PTMs

Phosphorylation

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Chac1

References

PMID: 22445366 by Chi Z., et al. Botch promotes neurogenesis by antagonizing Notch.

PMID: 23070364 by Kumar A., et al. Mammalian proapoptotic factor ChaC1 and its homologues function as gamma-glutamyl cyclotransferases acting specifically on glutathione.