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- Table of Contents
CHCHD3 Antibodies
AND CHCHD3 ELISA kits, CHCHD3 Proteins
Many biological assays use antibodies to detect CHCHD3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CHCHD3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CHCHD3 antibodies...
Designing an IHC experiment for CHCHD3? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the CHCHD3 IHC GuideCHCHD3 Infographic by Boster Bio
All CHCHD3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # A06593-2
100 μg/vial
Cat # A06593-2
100 μg/vial
CHCHD3 Overview
Facts about MICOS complex subunit MIC19.
MICOS complex subunit MIC19 (CHCHD3)
Part of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner tissue structure, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription.
Plays an essential role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:25781180). .
Gene Information
| Human | |
|---|---|
| Gene Name: | CHCHD3 |
| Uniprot: | Q9NX63 |
| Entrez: | 54927 |
Family
| Belongs to: |
|---|
| MICOS complex subunit Mic19 family |
Alternative Names
coiled-coil-helix-coiled-coil-helix domain containing 3; FLJ20420; mitochondrial
Molecular Weight
Mass (kDA):
26.152 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q32.3-q33 |
| Sequence: | 7; NC_000007.14 (132784862..133082158, complement) |
Tissue Specificity
Detected at low levels in brain, placenta, lung, liver, kidney and pancreas with increased levels in heart and skeletal muscle. Higher expression in primary lung cancers than in normal lung tissue.
Subcellular Localizations
Mitochondrion inner membrane; Lipid-anchor; Intermembrane side. Cytoplasm. Nucleus. Mitochondrion.
Diseases
- Malignant Neoplasms
- Autistic Disorder
- Malnutrition
- Inattention
- Neoplasms
- Neurodegenerative Disorders
- Pancreatic Neoplasm
- Nervous System Disorder
Interacting Proteins
- BLZF1
- CALCOCO2
- CCDC85B
- FANCL
- GMCL2
- GOLGA2
- KRT40
- LZTS2
- NOTCH2NL
- PDE4DIP
Pathways
- Protein Import
- Cartilage Development
- Cell Growth
- Oxidative Phosphorylation
- Localization
- Rna Interference
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CHCHD3
bosterbio.com/bosterbio-gene-info-cards/CHCHD3
References
PMID: 21081504 by Darshi M., et al. ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function.
PMID: 22114354 by Alkhaja A.K., et al. MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization.