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Chordin-like protein 2 Antibodies
AND CHRDL2 ELISA kits, Chordin-like protein 2 Proteins
Many biological assays use antibodies to detect Chordin-like protein 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Chordin-like protein 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Chordin-like protein 2 antibodies...
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CHRDL2 Infographic by Boster Bio
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CHRDL2 Overview
Facts about Chordin-like protein 2.
Chordin-like protein 2 (CHRDL2)
May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity).
Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation.
Gene Information
| Human | |
|---|---|
| Gene Name: | CHRDL2 |
| Uniprot: | Q6WN34 |
| Entrez: | 25884 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
BNF-1; Chordin like 2; Chordin-like 2; chordin-like protein 2; CHRDL2
Molecular Weight
Mass (kDA):
47.495 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q13.4 |
| Sequence: | 11; NC_000011.10 (74696428..74731426, complement) |
Tissue Specificity
Highly expressed in uterus. Moderately expressed in heart, liver, prostate, testis and ovary. Weakly expressed in skeletal muscle, kidney, spleen, small intestine and colon. Expressed in the secretory epithelial cells of uterine endometrium, fallopian tubes, endocervical glands, bladder and prostate, as well as the transitional epithelium of the urinary bladder, and in bone osteoblasts (at protein level). In normal cartilage, expression was confined in a few chondrocytes in the superficial zone as well as in the middle zone. In diseased cartilage coming from osteoarthritic patients, expression was limited to the middle zone of chondrocytes. Isoform 1 and isoform 2 are expressed in fetal cerebellum and heart, while only isoform 2 is detected in fetal spleen. Isoform 2 present in plasma.
Subcellular Localizations
[Isoform 1]: Secreted.; [Isoform 2]: Secreted.; [Isoform 3]: Cytoplasm.; [Isoform 4]: Cytoplasm.; [Isoform 5]: Cytoplasm.
Diseases
- Von Willebrand Disease
- Infective Disorder
- Congenital Abnormality
- Lung Neoplasms
- Cartilage Injury
- Colonic Neoplasms
- Trichinellosis
- Malignant Tumor Of Colon
- Degenerative Polyarthritis
- Tumor Angiogenesis
- Retinoblastoma
Pathways
- Osteoblast Differentiation
- Cell Activation
- Gastrulation
- Cell Proliferation
- Programmed Cell Death
- Cell Death
- Satellite Cell Activation
- Cell Differentiation
PTMs
- Glycoprotein
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CHRDL2
bosterbio.com/bosterbio-gene-info-cards/CHRDL2
References
PMID: 12853144 by Wu I., et al. BNF-1, a novel gene encoding a putative extracellular matrix protein, is overexpressed in tumor tissues.
PMID: 15094188 by Oren A., et al. hCHL2, a novel chordin-related gene, displays differential expression and complex alternative splicing in human tissues and during myoblast and osteoblast maturation.