CHST4 Antibodies

AND CHST4 ELISA kits, CHST4 Proteins

Many biological assays use antibodies to detect CHST4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CHST4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CHST4 antibodies...

We validate the specificity of these antibodies to CHST4 by testing them on tissues known to express CHST4 positively and negatively. Browse below to find the CHST4 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CHST4 Infographic by Boster Bio

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Carbohydrate sulfotransferase 4 (CHST4) (NM_005769) Human Over-expression Lysate

Human

$628
Cat # LS010164
20 µg, 100 µg

CHST4 Overview

Facts about Carbohydrate sulfotransferase 4.

CHST4 3D structure. Source: alphafold

Carbohydrate sulfotransferase 4 (CHST4)

Sulfotransferase that uses 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate contributor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within mucin-associated glycans that serve as SELL ligands. SELL ligands are found in high endothelial cells (HEVs) and play a central role in lymphocyte homing in sites of inflammation.

Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X receptors SPN/CD43, GLYCAM1 and MADCAM1. Also involved in biosynthesis of SELL ligand recognized by MECA-79 antibody.

Gene Information

Human
Gene Name:	CHST4
Uniprot:	Q8NCG5
Entrez:	10164

Family

Belongs to:

sulfotransferase 1 family

Alternative Names

carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4; Carbohydrate Sulfotransferase 4; CHST4; EC 2.8.2; EC 2.8.2.-; EC 2.8.2.17; EC 2.8.2.21; galactose/N-acetylglucosamine/N-acetylgalactosamine 6-O-sulfotransferase 3; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 3; GlcNAc6ST2; GlcNAc6ST-2; gn6st-2; GST3; GST-3; HECGLCNAC6ST; HEC-GlcNAc6ST; HEC-GLCNAC-6-ST; High endothelial cells N-acetylglucosamine 6-O-sulfotransferase; L-selectin ligand sulfotransferase; LSST; LSSTcarbohydrate sulfotransferase 4; N-acetylglucosamine 6-O-sulfotransferase 2

Molecular Weight

Mass (kDA):
45.134 kDA

Genomic Context


Human

Location:	16q22.2
Sequence:	16; NC_000016.10 (71526120..71538748)

Tissue Specificity

Specifically expressed in HEV. Weakly expressed in spleen. Not expressed in other tissues. Expressed in colonic mucinous adenocarcinoma.

Subcellular Localizations

Golgi apparatus membrane; Single-pass type II membrane protein.

Diseases

Inflammation
Autoimmunity
Cholangiocarcinoma
Fasciola Hepatica Infection
Cystic Fibrosis
Bile Duct Neoplasms
Salivary Gland Diseases
Intrahepatic Cholangiocarcinoma
Chronic Inflammation
Degenerative Polyarthritis

Arthritis
Fibrosis
Malignant Neoplasms
Rheumatoid Arthritis
Opisthorchiasis

Pathways

Sulfation
Glycosylation

PTMs

Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CHST4

References

PMID: 10330415 by Bistrup A., et al. Sulfotransferases of two specificities function in the reconstitution of high endothelial cell ligands for L-selectin.

PMID: 11439191 by Yeh J.-C., et al. Novel sulfated lymphocyte homing receptors and their control by a Core1 extension beta 1,3-N-acetylglucosaminyltransferase.