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- Table of Contents
CLEC4C Antibodies
AND CLEC4C ELISA kits, CLEC4C Proteins
Many biological assays use antibodies to detect CLEC4C, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CLEC4C in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CLEC4C antibodies...
Designing an IHC experiment for CLEC4C? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the CLEC4C IHC GuideCLEC4C Infographic by Boster Bio
All CLEC4C Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M07313
100 μg
Cat # M07313
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M07313-1
100 μg
Cat # M07313-1
100 μg
CLEC4C Overview
Facts about C-type lectin domain family 4 member C.
C-type lectin domain family 4 member C (CLEC4C)
Lectin-type cell surface receptor which might play a role in antigen shooting by dendritic cells (PubMed:11748283, PubMed:21880719, PubMed:25995448). Specifically recognizes non- sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man (PubMed:21880719, PubMed:25995448).
Binds to serum IgG (PubMed:25995448). Efficiently targets ligand into antigen- processing and peptide-loading compartments for presentation to T- cells (PubMed:11748283).
Gene Information
| Human | |
|---|---|
| Gene Name: | CLEC4C |
| Uniprot: | Q8WTT0 |
| Entrez: | 170482 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
BDCA2; BDCA-2; BDCA2MGC125791; blood dendritic cell antigen 2 protein; Blood dendritic cell antigen 2; CD303 antigen; CD303; CLEC4C; CLECSF11; CLECSF11PRO34150; CLECSF7; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamilymember 11; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamilymember 7; C-type lectin domain family 4 member C; C-type lectin superfamily member 7; dendritic cell lectin b; Dendritic lectin; DLEC; DLECMGC125792; HECL; HECLMGC125793; MGC125789; PRO34150
Molecular Weight
Mass (kDA):
25.038 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12p13.31 |
| Sequence: | 12; NC_000012.12 (7729245..7751600, complement) |
Tissue Specificity
Expressed in plasmacytoid dendritic cells (PDCs). Constitutively expressed in immature monocyte-derived dendritic cells (iMDDC) and is significantly down-regulated upon maturation with LPS but not with TNF-alpha.
Subcellular Localizations
Cell membrane; Single-pass type II membrane protein.
Diseases
- Neoplasms
- Skin Neoplasms
- Lupus Erythematosus, Systemic
- Autoimmune Reaction
- Lymphoma
- Autoimmune Diseases
- Hiv Infections
- Malignant Neoplasms
- Carcinoma
- Inflammation
- Leukemia
- Hepatitis
- Malignant Paraganglionic Neoplasm
Pathways
- Secretion
- Immune Response
- Pathogenesis
- Cell Activation
- Cell Proliferation
- Endocytosis
- Cytokine Production
- Innate Immune Response
- Localization
- Clathrin-mediated Endocytosis
- Dendritic Cell Proliferation
- T Cell Activation
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CLEC4C
bosterbio.com/bosterbio-gene-info-cards/CLEC4C
References
PMID: 11536172 by Arce I., et al. Molecular and genomic characterization of human DLEC, a novel member of the C-type lectin receptor gene family preferentially expressed on monocyte-derived dendritic cells.
PMID: 11748283 by Dzionek A., et al. BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction.