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- Table of Contents
CLN5 Antibodies
AND CLN5 ELISA kits, CLN5 Proteins
Many biological assays use antibodies to detect CLN5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CLN5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CLN5 antibodies...
Designing an IHC experiment for CLN5? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the CLN5 IHC GuideCLN5 Infographic by Boster Bio
All CLN5 Products
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CLN5 Overview
Facts about Ceroid-lipofuscinosis neuronal protein 5.
Ceroid-lipofuscinosis neuronal protein 5 (CLN5)
Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes into the trans-Golgi network by controlling the recruitment of retromer complex into the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex into the endosomal membrane (PubMed:22431521).
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Gene Information
| Human | |
|---|---|
| Gene Name: | CLN5 |
| Uniprot: | O75503 |
| Entrez: | 1203 |
Family
| Belongs to: |
|---|
| CLN5 family |
Alternative Names
ceroid-lipofuscinosis neuronal protein 5; ceroid-lipofuscinosis, neuronal 5; CLN5; FLJ90628
Molecular Weight
Mass (kDA):
41.497 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 13q22.3 |
| Sequence: | 13; NC_000013.11 (76992081..77005117) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
[Ceroid-lipofuscinosis neuronal protein 5, secreted form]: Lysosome.; [Ceroid-lipofuscinosis neuronal protein 5]: Membrane; Single-pass type II membrane protein. An amphipathic anchor region facilitates its association with the membrane.
Diseases
- Neuronal Ceroid-lipofuscinoses
- Neurodegenerative Disorders
- Epilepsy
- Ceroid Lipofuscinosis, Neuronal, 5
- Late-infantile Neuronal Ceroid Lipfuscinosis
- Infantile Neuronal Ceroid Lipofuscinosis
- Blind Vision
- Juvenile Neuronal Ceroid Lipfuscinosis
- Atrophy
- Nerve Degeneration
- Lysosomal Storage Diseases
Pathways
- Pathogenesis
- Localization
- Transport
- Cell Death
- Glycosylation
- Cell Proliferation
- Gene Silencing
- Induction Of Apoptosis
- Meiosis Ii
- Mitosis
- Aging
- Immune Response
- Astrocyte Activation
PTMs
- Glycosylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CLN5
bosterbio.com/bosterbio-gene-info-cards/CLN5
References
PMID: 9662406 by Savukoski M., et al. CLN5, a novel gene encoding a putative transmembrane protein mutated in Finnish variant late infantile neuronal ceroid lipofuscinosis.
PMID: 11971870 by Isosomppi J., et al. Lysosomal localization of the neuronal ceroid lipofuscinosis CLN5 protein.