CLN5 Antibodies

AND CLN5 ELISA kits, CLN5 Proteins

Many biological assays use antibodies to detect CLN5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CLN5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CLN5 antibodies...

We validate the specificity of these antibodies to CLN5 by testing them on tissues known to express CLN5 positively and negatively. Browse below to find the CLN5 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CLN5 Infographic by Boster Bio

All CLN5 Products

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Anti-CLN5 Antibody

13 Q&As

Western Blot analysis of 293T cells using CLN5 Polyclonal Antibody diluted at 1:1000

Western blot analysis of the lysates from COLO205 cells using CLN5 antibody

Human, Mouse, Rat

ELISA, WB

$399
Cat # A04893-1
100μl

Anti-CLN5 Antibody

Western blot (WB) analysis of CLN5 pAb at 1:500 dilution
Lane1:PMVEC whole cell lysate(40ug)
Lane2:AML-12 whole cell lysate(40ug)
Lane3:L02 whole cell lysate(40ug)
Lane4:A549 whole cell lysate(40ug)

Immunohistochemistry of paraffin-embedded human appendix using CLN5 antibody at dilution of 1:150

Human, Mouse, Rat

IHC, WB

$405
Cat # A04893-2
100ul

CLN5 (NM_006493) Human Over-expression Lysate

Human

$628
Cat # LS001203
20 µg, 100 µg

CLN5 Overview

Facts about Ceroid-lipofuscinosis neuronal protein 5.

CLN5 3D structure. Source: alphafold

Ceroid-lipofuscinosis neuronal protein 5 (CLN5)

Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes into the trans-Golgi network by controlling the recruitment of retromer complex into the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex into the endosomal membrane (PubMed:22431521).

Gene Information

Human
Gene Name:	CLN5
Uniprot:	O75503
Entrez:	1203

Family

Belongs to:

CLN5 family

Alternative Names

ceroid-lipofuscinosis neuronal protein 5; ceroid-lipofuscinosis, neuronal 5; CLN5; FLJ90628

Molecular Weight

Mass (kDA):
41.497 kDA

Genomic Context


Human

Location:	13q22.3
Sequence:	13; NC_000013.11 (76992081..77005117)

Tissue Specificity

Ubiquitous.

Subcellular Localizations

[Ceroid-lipofuscinosis neuronal protein 5, secreted form]: Lysosome.; [Ceroid-lipofuscinosis neuronal protein 5]: Membrane; Single-pass type II membrane protein. An amphipathic anchor region facilitates its association with the membrane.

Diseases

Neuronal Ceroid-lipofuscinoses
Neurodegenerative Disorders
Epilepsy
Ceroid Lipofuscinosis, Neuronal, 5
Late-infantile Neuronal Ceroid Lipfuscinosis
Infantile Neuronal Ceroid Lipofuscinosis
Blind Vision
Juvenile Neuronal Ceroid Lipfuscinosis
Atrophy
Nerve Degeneration
Lysosomal Storage Diseases

Dementia
Visual Impairment
Ataxia
Nervousness
Northern Epilepsy Syndrome
Brain Diseases

Pathways

Pathogenesis
Localization
Transport
Cell Death
Glycosylation
Cell Proliferation
Gene Silencing
Induction Of Apoptosis
Meiosis Ii
Mitosis
Aging
Immune Response
Astrocyte Activation

Neurogenesis
Pigmentation
Metaphase
Lysosomal Transport
Myelination
Translation
Interphase

PTMs

Glycosylation
Cleavage

Phosphorylation
Depalmitoylation

Deglycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CLN5

References

PMID: 9662406 by Savukoski M., et al. CLN5, a novel gene encoding a putative transmembrane protein mutated in Finnish variant late infantile neuronal ceroid lipofuscinosis.

PMID: 11971870 by Isosomppi J., et al. Lysosomal localization of the neuronal ceroid lipofuscinosis CLN5 protein.