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Chemokine-like receptor 1 Antibodies
AND CMKLR1 ELISA kits, Chemokine-like receptor 1 Proteins
Many biological assays use antibodies to detect Chemokine-like receptor 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Chemokine-like receptor 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Chemokine-like receptor 1 antibodies...
Designing an IHC experiment for Chemokine-like receptor 1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the CMKLR1 IHC GuideCMKLR1 Infographic by Boster Bio
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CMKLR1 Overview
Facts about Chemokine-like receptor 1.
Chemokine-like receptor 1 (CMKLR1)
Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid based molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis.
Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF- kappa-B. Positively regulates adipogenesis and adipocyte metabolism.
Gene Information
| Human | |
|---|---|
| Gene Name: | CMKLR1 |
| Uniprot: | Q99788 |
| Entrez: | 1240 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor 1 family |
Alternative Names
CHEMERINR; chemokine receptor-like 1; chemokine-like receptor 1; ChemR23; cmklr1; Dez; Gpcr27; G-protein coupled receptor ChemR23; G-protein coupled receptor DEZ; MGC126105; MGC126106; orphan G-protein coupled receptor, Dez
Molecular Weight
Mass (kDA):
42.322 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q23.3 |
| Sequence: | 12; NC_000012.12 (108288044..108339347, complement) |
Tissue Specificity
Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands. Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues and myeloid tissues. Expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus, appendix, lymph node, bone marrow and fetal liver. Among leukocyte populations abundant expression in monocyte-derived macrophage and immature dendritic cells (DCs). High expression in blood monocytes and low levels in polymorphonuclear cells and T-cells. Expressed on endothelial cells. Highly expressed in differentiating adipocytes.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein.
Diseases
- Inflammation
- Obesity
- Cardiovascular Diseases
- Diabetes Mellitus
- Neoplasms
- Insulin Resistance
- Psoriasis
- Diabetes Mellitus, Non-insulin-dependent
- Tissue Adhesions
- Peritonitis
- Pneumonia
- Immunologic Deficiency Syndromes
- Malignant Neoplasms
Pathways
- Chemotaxis
- Secretion
- Cell Migration
- Coagulation
- Immune Response
- Pathogenesis
- Glucose Homeostasis
- Inflammatory Response
- Cell Proliferation
- Transport
- Phagocytosis
- Fibrinolysis
- Bone Development
PTMs
- Phosphorylation
Research Areas
- GPCR
- Immunology
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CMKLR1
bosterbio.com/bosterbio-gene-info-cards/CMKLR1
References
PMID: 9144535 by Methner A., et al. A novel G protein-coupled receptor with homology to neuropeptide and chemoattractant receptors expressed during bone development.
PMID: 9603476 by Samson M., et al. ChemR23, a putative chemoattractant receptor, is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1 strains.