CNOT4 Antibodies

AND CNOT4 ELISA kits, CNOT4 Proteins

Many biological assays use antibodies to detect CNOT4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CNOT4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CNOT4 antibodies...

We validate the specificity of these antibodies to CNOT4 by testing them on tissues known to express CNOT4 positively and negatively. Browse below to find the CNOT4 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for CNOT4? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the CNOT4 IHC Guide

CNOT4 Infographic by Boster Bio

All CNOT4 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

CNOT4 (NM_013316) Human Over-expression Lysate

CNOT4 Human Over-expression Lysates NM_001008225

Human

$960
Cat # LS004850
20 µg, 100 µg

Anti-CNOT4 Antibody

Immunohistochemistry analysis of paraffin-embedded human testis tissue, using CNOT4 Antibody

Western blot analysis of lysates from Jurkat and K562 cells, using CNOT4 Antibody

Human, Mouse, Rat

ELISA, IF, IHC, ICC, WB

$335
Cat # A08405
100ul

Anti-CNOT4 Antibody

Human, Mouse

$299
Cat # M08405
80 µl

CNOT4 (NM_001008225) Human Recombinant Protein

Coomassie blue staining of purified CNOT4 protein

$1249
Cat # PROTO95628
20 µg

CNOT4 Overview

Facts about CCR4-NOT transcription complex subunit 4.

CNOT4 3D structure. Source: alphafold

CCR4-NOT transcription complex subunit 4 (CNOT4)

Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins (PubMed:11823428, PubMed:22159038, PubMed:26575292). Involved in activation of this JAK/STAT pathway (PubMed:11823428, PubMed:22159038).

Catalyzes ubiquitination of methylated RBM15 (PubMed:26575292). .

Gene Information

Human
Gene Name:	CNOT4
Uniprot:	O95628
Entrez:	4850

Family

Belongs to:

No superfamily

Alternative Names

CCR4-associated factor 4; CCR4-NOT transcription complex, subunit 4; E3 ubiquitin-protein ligase CNOT4; EC 6.3.2.-; NOT4yeast) homolog

Molecular Weight

Mass (kDA):
63.51 kDA

Genomic Context


Human

Location:	7q33
Sequence:	7; NC_000007.14 (135361795..135510127, complement)

Subcellular Localizations

Cytoplasm. Nucleus.

Pathways

Transport
Cell Proliferation
Fertilization
Localization
Embryo Development
Cytokinesis

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CNOT4

References

PMID: 10637334 by Albert T.K., et al. Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits.

PMID: 11823428 by Albert T.K., et al. Identification of a ubiquitin-protein ligase subunit within the CCR4- NOT transcription repressor complex.