COPRS Antibodies

AND COPRS ELISA kits, COPRS Proteins

Many biological assays use antibodies to detect COPRS, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with COPRS in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop COPRS antibodies...

We validate the specificity of these antibodies to COPRS by testing them on tissues known to express COPRS positively and negatively. Browse below to find the COPRS antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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COPRS Infographic by Boster Bio

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COPRS (NM_018405) Human Over-expression Lysate

Human

$628
Cat # LS055352
20 µg, 100 µg

COPRS Overview

Facts about Coordinator of PRMT5 and differentiation stimulator.

COPRS 3D structure. Source: alphafold

Coordinator of PRMT5 and differentiation stimulator (COPRS)

Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4'Arg-3' methylation mediated by PRMT5, but not histone H3'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5.

Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it functions by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression.

Gene Information

Human
Gene Name:	COPRS
Uniprot:	Q9NQ92
Entrez:	55352

Family

Belongs to:

No superfamily

Alternative Names

C17orf79; chromosome 17 open reading frame 79; cooperator of PRMT5; COPR5; FLJ21119; HSA272196; Protein TTP1; TTP1

Molecular Weight

Mass (kDA):
20.066 kDA

Genomic Context


Human

Location:	17q11.2
Sequence:	17; NC_000017.11 (31851871..31859244, complement)

Subcellular Localizations

Nucleus.

Diseases

Chronic Obstructive Airway Disease
Mutation, Out-of-frame
Headache
Fish Diseases
Pseudomonas Infections
Physiological Stress

Interacting Proteins

HIST1H4A
PRMT5

Pathways

Transport
Nodulation
Fermentation
Aerobic Respiration
Photosynthesis
Biofilm Formation

Virulence

PTMs

Acetylation

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/COPRS

References

PMID: 10843809 by Jenne D.E., et al. A common set of at least 11 functional genes is lost in the majority of NF1 patients with gross deletions.

PMID: 18404153 by Lacroix M., et al. The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5.