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- Table of Contents
CREB3 Antibodies
AND CREB3 ELISA kits, CREB3 Proteins
Many biological assays use antibodies to detect CREB3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CREB3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CREB3 antibodies...
Designing a Western blot for CREB3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CREB3 Western Blot GuideCREB3 Infographic by Boster Bio
All CREB3 Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A04591-1
100 μg/vial
Cat # A04591-1
100 μg/vial
CREB3 Overview
Facts about Cyclic AMP-responsive element-binding protein 3.
Cyclic AMP-responsive element-binding protein 3 (CREB3)
Endoplasmic reticulum (ER)-bound sequence-specific transcription factor that directly binds DNA and activates transcription (PubMed:9271389, PubMed:19779205, PubMed:10984507, PubMed:15845366, PubMed:16940180). Plays a role in the unfolded protein response (UPR), promoting cell survival versus ER stress- induced apoptotic cell death (PubMed:15845366, PubMed:16940180).
Also involved in cell proliferation, migration and differentiation, tumor suppression and inflammatory gene expression. Acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration (PubMed:19779205, PubMed:15001559, PubMed:17296613).
Gene Information
| Human | |
|---|---|
| Gene Name: | CREB3 |
| Uniprot: | O43889 |
| Entrez: | 10488 |
Family
| Belongs to: |
|---|
| bZIP family |
Alternative Names
basic leucine zipper protein; cAMP responsive element binding protein 3 (luman); cAMP responsive element binding protein 3; cAMP-responsive element-binding protein 3; CREB-3; cyclic AMP response element (CRE)-binding protein/activating transcriptionfactor 1; cyclic AMP-responsive element-binding protein 3; LUMAN; LZIPMGC15333; MGC19782; Transcription factor LZIP-alpha
Molecular Weight
Mass (kDA):
41.379 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9p13.3 |
| Sequence: | 9; NC_000009.12 (35732666..35736999) |
Tissue Specificity
Ubiquitously expressed (PubMed:9271389, PubMed:19779205). Expressed in dendritic cells (DC). Weakly expressed in monocytes (at protein level) (PubMed:20546900).
Subcellular Localizations
[Isoform 1]: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus. Colocalizes with HCFC1 in neuronal cell bodies of the trigeminal ganglia (PubMed:10623756). Colocalizes with DCSTAMP in the ER membrane of immature dendritic cell (DC) (PubMed:20546900). Colocalizes with CANX, CCR1, HCFC1 in the ER membrane (PubMed:10623756).; [Isoform 2]: Nucleus. Cytoplasm. Predominantly in the nucleus (PubMed:19779205). Not associated with membranes (PubMed:19779205).; [Processed cyclic AMP-responsive element-binding protein 3]: Nucleus. Upon RIP activation the transcriptiona
Diseases
- Neoplasms
- Malignant Neoplasms
- Neoplasm Metastasis
- Cholangiocarcinoma
- Carcinoma
- Mammary Neoplasms
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Breast
- Sarcoma
- Feline Urological Syndrome
- Low Grade Fibromyxoid Sarcoma
Interacting Proteins
- AGER
- ALG3
- ALG8
- APOD
- AQP1
- AQP2
- AQP4
- C1S
- C2
- CCR1
Pathways
- Proteolysis
- Cell Migration
- Cell Proliferation
- Localization
- Cell Cycle
- Transport
- Chemotaxis
- Dna Replication
- Pathogenesis
- Golgi Localization
- Immune Response
- Response To Brefeldin A
- Oxidative Phosphorylation
PTMs
- Cleavage
- Phosphorylation
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CREB3
bosterbio.com/bosterbio-gene-info-cards/CREB3
References
PMID: 9271389 by Lu R., et al. Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor.
PMID: 9389645 by Freiman R.N., et al. Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP.