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In response to ER stress, transported to the Golgi, where it is cleaved at a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The published N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes.
|Sequence:||7; NC_000007.14 (137874979..138002086, complement)|
Widely expressed with highest levels in placenta, lung, spleen and intestine, and lowest levels in heart, brain, skeletal muscle, thymus, colon and leukocytes. In fetal tissues, the weakest expression is detected in brain and heart.
Endoplasmic reticulum membrane; Single-pass type II membrane protein. ER membrane resident protein. Upon ER stress, translocated to the Golgi apparatus where it is cleaved. The cytosolic N-terminal fragment (processed cyclic AMP-responsive element-binding protein 3-like protein 1) is transported into the nucleus.; [Processed cyclic AMP-responsive element-binding protein 3-like protein 2]: Nucleus. Upon ER stress, translocated into the nucleus.