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- Table of Contents
CREB-binding protein Antibodies
AND CREBBP ELISA kits, CREB-binding protein Proteins
Many biological assays use antibodies to detect CREB-binding protein, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CREB-binding protein in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CREB-binding protein antibodies...
Designing a Western blot for CREB-binding protein? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CREBBP Western Blot GuideDesigning an IHC experiment for CREB-binding protein? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the CREBBP IHC GuideCREBBP Infographic by Boster Bio
All CREBBP Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00205-1
20μL, 40μL, 100μL, 200μL
Cat # M00205-1
20μL, 40μL, 100μL, 200μL
Human, Mouse, Rat
ELISA
$480
Cat # EKC1924
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1924
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse
ELISA
$480
Cat # EKC1141
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1141
1 kit, containing one 96-well plate and all necessary reagents
Human
ELISA
$540
Cat # EKC2585
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2585
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2154
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2154
1 kit, containing two 96-well plates and all necessary reagents
Human
ELISA
$540
Cat # EKC2078
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2078
1 kit, containing two 96-well plates and all necessary reagents
CREBBP Overview
Facts about CREB-binding protein.
CREB-binding protein (CREBBP)
Acetylates histones, providing a specific tag for transcriptional activation. Additionally acetylates non-histone proteins, like NCOA3 and FOXO1.
Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK- ARNTL/BMAL1 heterodimers.
Gene Information
| Human | |
|---|---|
| Gene Name: | CREBBP |
| Uniprot: | Q92793 |
| Entrez: | 1387 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CBP; CBPRTS; CREB binding protein; CREB-binding protein; CREBBP; EC 2.3.1.48; KAT3A; RSTS; RTS; Rubinstein-Taybi syndrome
Molecular Weight
Mass (kDA):
265.351 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16p13.3 |
| Sequence: | 16; NC_000016.10 (3725054..3880727, complement) |
Subcellular Localizations
Cytoplasm. Nucleus. Recruited to nuclear bodies by SS18L1/CREST. In the presence of ALX1 relocalizes from the cytoplasm to the nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Leukemia
- Rubinstein-taybi Syndrome
- Myeloid Leukemia
- Leukemia, Myelocytic, Acute
- Mammary Neoplasms
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Breast
- Carcinoma
- Neurodegenerative Disorders
- Inflammation
Interacting Proteins
- AKT1
- AR
- COPS2
- CREB1
- CTNNB1
- DAXX
- FOXO1
- FOXO3
- HIF1A
- HIST1H4A
Pathways
- Histone Acetylation
- Cell Cycle
- Pathogenesis
- Localization
- Cell Proliferation
- Chromatin Remodeling
- Cell Death
- Methylation
- Cell Differentiation
- Long-term Memory
- Regulation Of Gene Expression
- Cell Growth
- Viral Replication
PTMs
- Phosphorylation
- Acetylation
- Methylation
- Deacetylation
- Dephosphorylation
- Glycosylation
- Ubiquitination
- Cleavage
- Hydroxylation
Research Areas
- Stem Cell Signaling Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CREBBP
bosterbio.com/bosterbio-gene-info-cards/CREBBP
References
PMID: 9238046 by Sobulo O.M., et al. MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3).
PMID: 9177780 by Giles R.H., et al. Construction of a 1.2-Mb contig surrounding, and molecular analysis of, the human CREB-binding protein (CBP/CREBBP) gene on chromosome 16p13.3.