CREM Antibodies

cAMP-responsive element modulator (CREM)

Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors.

Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550). .

Gene Information

Human
Gene Name:	CREM
Uniprot:	Q03060
Entrez:	1390

Family

Belongs to:
bZIP family

Alternative Names

cAMP response element modulator; cAMP responsive element modulator; cAMP-responsive element modulator; hCREM 2alpha-b protein; hCREM 2beta-a protein; hCREM-2; ICER; inducible cAMP early repressor ICER; Inducible cAMP early repressor; MGC111110; MGC17881; MGC41893

Molecular Weight

Mass (kDA):
37.006 kDA

Genomic Context

Human
Location:	10p11.21
Sequence:	10; NC_000010.11 (35126830..35212958)

Tissue Specificity

Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes.

Subcellular Localizations

Nucleus.; [Isoform 6]: Cytoplasm. Nucleus.

Diseases

• Infertility
• Neoplasms
• Pituitary Diseases
• Male Infertility
• Lupus Erythematosus, Systemic
• Malignant Neoplasms
• Leukemia
• Growth Arrest
• Nervousness
• Autoimmune Reaction
• Hemophagocytic Lymphohistiocytosis, Familial, 5
• Oligospermia
• Autoimmune Diseases

• Hyperplasia
• Diabetes Mellitus
• Leukemia, T-cell
• Inflammation
• Cell Transformation, Neoplastic
• Nerve Degeneration
• Carcinoma

Interacting Proteins

• DNMT3A
• HPCA
• HPCAL1

Pathways

• Spermatogenesis
• Localization
• Cell Proliferation
• Secretion
• Cell Death
• Cell Differentiation
• Pachytene
• Cell Cycle
• Cell Activation
• Methylation
• Reverse Transcription
• Translation
• Immune Response

• Cell Development
• Pathogenesis
• Sperm Motility
• Transport
• Response To Camp
• Sensitization
• Meiosis

PTMs

• Phosphorylation
• Methylation
• Acetylation
• Dephosphorylation
• Demethylation

• Deacetylation
• Reduction
• Sulphation
• Cleavage
• Oxidation

• Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CREM

Best Uses Of The CREM Marker

You're in the right place if CREM is something that interests you. The CREM cell-based ELISA kit is a fast and convenient CREM marker suitable for all types. It measures the CREM level in cell cultures to monitor treatment effects. Although it's not available to purchase individually, you can still get credit for your review by being first to give the kit a try. The CREM cell based ELISA system is universally applicable so you can get credit for any review.