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- Table of Contents
CREM Antibodies
AND CREM ELISA kits, CREM Proteins
Many biological assays use antibodies to detect CREM, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CREM in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CREM antibodies...
Designing a Western blot for CREM? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CREM Western Blot GuideDesigning an IHC experiment for CREM? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the CREM IHC GuideCREM Infographic by Boster Bio
All CREM Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$480
Cat # EKC1771
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1771
1 kit, containing one 96-well plate and all necessary reagents
CREM Overview
Facts about cAMP-responsive element modulator.
cAMP-responsive element modulator (CREM)
Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors.
Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550). .
Gene Information
| Human | |
|---|---|
| Gene Name: | CREM |
| Uniprot: | Q03060 |
| Entrez: | 1390 |
Family
| Belongs to: |
|---|
| bZIP family |
Alternative Names
cAMP response element modulator; cAMP responsive element modulator; cAMP-responsive element modulator; hCREM 2alpha-b protein; hCREM 2beta-a protein; hCREM-2; ICER; inducible cAMP early repressor ICER; Inducible cAMP early repressor; MGC111110; MGC17881; MGC41893
Molecular Weight
Mass (kDA):
37.006 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10p11.21 |
| Sequence: | 10; NC_000010.11 (35126830..35212958) |
Tissue Specificity
Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes.
Subcellular Localizations
Nucleus.; [Isoform 6]: Cytoplasm. Nucleus.
Diseases
- Infertility
- Neoplasms
- Pituitary Diseases
- Male Infertility
- Lupus Erythematosus, Systemic
- Malignant Neoplasms
- Leukemia
- Growth Arrest
- Nervousness
- Autoimmune Reaction
- Hemophagocytic Lymphohistiocytosis, Familial, 5
- Oligospermia
- Autoimmune Diseases
Interacting Proteins
- DNMT3A
- HPCA
- HPCAL1
Pathways
- Spermatogenesis
- Localization
- Cell Proliferation
- Secretion
- Cell Death
- Cell Differentiation
- Pachytene
- Cell Cycle
- Cell Activation
- Methylation
- Reverse Transcription
- Translation
- Immune Response
PTMs
- Phosphorylation
- Methylation
- Acetylation
- Dephosphorylation
- Demethylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CREM
bosterbio.com/bosterbio-gene-info-cards/CREM
References
PMID: 7916662 by Masquilier D., et al. Human CREM gene: evolutionary conservation, chromosomal localization, and inducibility of the transcript.
PMID: 8206879 by Fujimoto T., et al. Novel isoforms of human cyclic AMP-responsive element modulator (hCREM) mRNA.