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- Table of Contents
CSRP3 Antibodies
AND CSRP3 ELISA kits, CSRP3 Proteins
Many biological assays use antibodies to detect CSRP3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CSRP3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CSRP3 antibodies...
Designing an IHC experiment for CSRP3? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the CSRP3 IHC GuideCSRP3 Infographic by Boster Bio
All CSRP3 Products
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Specificity
Applications
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CSRP3 Overview
Facts about Cysteine and glycine-rich protein 3.
Cysteine and glycine-rich protein 3 (CSRP3)
Positive regulator of myogenesis. Acts as cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6.
Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and might promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis (By similarity). Plays a crucial and specific role in the business of cytosolic structures in cardiomyocytes.
Gene Information
| Human | |
|---|---|
| Gene Name: | CSRP3 |
| Uniprot: | P50461 |
| Entrez: | 8048 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Cardiac LIM protein; CLPMGC14488; CMD1Mcardiac LIM domain protein; CMH12; CRP3cysteine and glycine-rich protein 3; cysteine and glycine-rich protein 3 (cardiac LIM protein); Cysteine-rich protein 3; LIM domain only 4; LIM domain protein, cardiac; LMO4; MLPMGC61993; Muscle LIM protein
Molecular Weight
Mass (kDA):
20.969 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p15.1 |
| Sequence: | 11; NC_000011.10 (19182030..19201983, complement) |
Tissue Specificity
Cardiac and slow-twitch skeletal muscles. Isoform 2 is expressed in striated muscle. Isoform 2 is specifically expressed at higher levels in patients with neuromuscular diseases, such as limb-girdle muscular dystrophy 2A (LGMD2A), Duchenne muscular dystrophy (DMD) and dermatomyositis (PubMed:24860983).
Subcellular Localizations
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Cytoplasm, myofibril, sarcomere. Nucleocytoplasmic shuttling protein. Mainly cytoplasmic. In the Z line, found associated with GLRX3 (By similarity).; [Isoform 2]: Cytoplasm, myofibril, sarcomere, Z line.
Diseases
- Cardiomyopathies
- Hypertrophy
- Hypertrophic Cardiomyopathy
- Cardiomyopathy, Dilated
- Cardiomyopathy, Familial Idiopathic
- Heart Failure
- Heart Diseases
- Sudden Cardiac Death
- Atrophy
- Muscular Atrophy
- Malnutrition
Interacting Proteins
- ACTN2
- CFL2
- NRAP
- TCAP
Pathways
- Localization
- Transport
- Pathogenesis
- Cell Adhesion
- Muscle Cell Proliferation
- Cell Proliferation
- Cellular Homeostasis
- Energy Homeostasis
- Muscle Atrophy
- Eye Morphogenesis
- Cell Cycle
- Heart Contraction
PTMs
- Phosphorylation
Research Areas
- DNA Repair
- DNA replication, Transcription, Translation and Splicing
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CSRP3
bosterbio.com/bosterbio-gene-info-cards/CSRP3
References
PMID: 7490106 by Fung Y.W., et al. Mapping of a human LIM protein (CLP) to human chromosome 11p15.1 by fluorescence in situ hybridization.
PMID: 24860983 by Vafiadaki E., et al. Muscle lim protein isoform negatively regulates striated muscle actin dynamics and differentiation.