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- Table of Contents
Cathepsin K Antibodies
AND CTSK ELISA kits, Cathepsin K Proteins
Many biological assays use antibodies to detect Cathepsin K, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cathepsin K in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cathepsin K antibodies...
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CTSK Infographic by Boster Bio
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CTSK Overview
Facts about Cathepsin K.
Cathepsin K (CTSK)
Closely involved in osteoclastic bone resorption and might participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH.
May play an important role in extracellular matrix degradation. .
Gene Information
| Human | |
|---|---|
| Gene Name: | CTSK |
| Uniprot: | P43235 |
| Entrez: | 1513 |
Family
| Belongs to: |
|---|
| peptidase C1 family |
Alternative Names
cathepsin K (pycnodysostosis); Cathepsin K; Cathepsin O; cathepsin O1; Cathepsin O2; Cathepsin X; CTS02; CTSK; CTSO; CTSO1; CTSO2; EC 3.4.22; EC 3.4.22.38; MGC23107; PKND; PYCD
Molecular Weight
Mass (kDA):
36.966 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q21.3 |
| Sequence: | 1; NC_000001.11 (150796208..150808260, complement) |
Tissue Specificity
Predominantly expressed in osteoclasts (bones).
Subcellular Localizations
Lysosome. Secreted. Apical cell membrane; Peripheral membrane protein; Extracellular side. Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells.
Diseases
- Osteoporosis
- Neoplasms
- Arthritis
- Pycnodysostosis
- Malignant Neoplasms
- Osteopenia
- Albers-schonberg Disease
- Rheumatoid Arthritis
- Inflammation
- Neoplasm Metastasis
- Bone Neoplasms
- Bone Diseases
- Fracture
Pathways
- Bone Resorption
- Osteoclast Differentiation
- Bone Remodeling
- Localization
- Pathogenesis
- Secretion
- Proteolysis
- Transport
- Aging
- Tissue Remodeling
- Osteoblast Differentiation
- Phagocytosis
- Ossification
PTMs
- Cleavage
- Phosphorylation
- Reduction
- Glycosylation
- Methylation
- Nitrosylation
Research Areas
- Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CTSK
bosterbio.com/bosterbio-gene-info-cards/CTSK
References
PMID: 7805878 by Shi G.-P., et al. Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2.
PMID: 7818555 by Inaoka T., et al. Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in bone.
2 Publications of Boster Cathepsin K Antibodies & ELISA Kits
- PubMed ID: 10.1016/j.trsl.2020.04.011, Cathepsin B deficiency ameliorates liver lipid deposition, inflammatory cell inf...
- PubMed ID: 28199984, Wang J, You H, Qi J, Yang C, Ren Y, Cheng H. Oncotarget. 2017 Mar 7;8(10):17012-...
*More publications can be found for each product on its corresponding product page