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- Table of Contents
Cytochrome P450 2A6 Antibodies
AND CYP2A6 ELISA kits, Cytochrome P450 2A6 Proteins
Many biological assays use antibodies to detect Cytochrome P450 2A6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cytochrome P450 2A6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cytochrome P450 2A6 antibodies...
Designing a Western blot for Cytochrome P450 2A6? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CYP2A6 Western Blot GuideCYP2A6 Infographic by Boster Bio
All CYP2A6 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
WB
$370
Cat # A00947-2
100 μg/vial
Cat # A00947-2
100 μg/vial
Human
$960
Cat # LS001548
20 µg, 100 µg
Cat # LS001548
20 µg, 100 µg
CYP2A6 Overview
Facts about Cytochrome P450 2A6.
Cytochrome P450 2A6 (CYP2A6)
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide.
Competent in the metabolic activation of aflatoxin B1. Constitutes the significant nicotine C-oxidase.
Gene Information
| Human | |
|---|---|
| Gene Name: | CYP2A6 |
| Uniprot: | P11509 |
| Entrez: | 1548 |
Family
| Belongs to: |
|---|
| cytochrome P450 family |
Alternative Names
Coumarin 7-hydroxylase; CPA6; CYP2A3P450C2A; CYP2AEC 1.14.14.1; CYPIIA6; cytochrome P450 2A6; Cytochrome P450 IIA3; Cytochrome P450(I); cytochrome P450, family 2, subfamily A, polypeptide 6; cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6; flavoprotein-linked monooxygenase; P450PB; xenobiotic monooxygenase
Molecular Weight
Mass (kDA):
56.517 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.2 |
| Sequence: | 19; NC_000019.10 (40843541..40850447, complement) |
Tissue Specificity
Liver.
Subcellular Localizations
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Diseases
- Malignant Neoplasms
- Malignant Neoplasm Of Lung
- Neoplasms
- Lung Neoplasms
- Carcinoma
- Tobacco Use Disorder
- Nicotine Dependence
- Liver Carcinoma
- Hepatitis
- Adenocarcinoma
- Malignant Squamous Cell Neoplasm
- Salmonella Infections
- Tobacco Dependence Syndrome
Pathways
- Excretion
- Conjugation
- Gene Conversion
- Pathogenesis
- Demethylation
- Dna Repair
- Translation
- Localization
- Secretion
- Transport
- Cell Cycle
- Methylation
- Cell Death
PTMs
- Hydroxylation
- Oxidation
- Demethylation
- Reduction
- Cleavage
Research Areas
- Lipid and Metabolism
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CYP2A6
bosterbio.com/bosterbio-gene-info-cards/CYP2A6
References
PMID: 2726448 by Miles J.S., et al. Close linkage of the human cytochrome P450IIA and P450IIB gene subfamilies: implications for the assignment of substrate specificity.
PMID: 2748347 by Yamano S., et al. cDNA and deduced amino acid sequences of human P450 IIA3 (CYP2A3).