Cytochrome P450 2C8 Antibodies

AND CYP2C8 ELISA kits, Cytochrome P450 2C8 Proteins

Many biological assays use antibodies to detect Cytochrome P450 2C8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cytochrome P450 2C8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cytochrome P450 2C8 antibodies...

We validate the specificity of these antibodies to Cytochrome P450 2C8 by testing them on tissues known to express CYP2C8 positively and negatively. Browse below to find the CYP2C8 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CYP2C8 Infographic by Boster Bio

All CYP2C8 Products

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Product

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Specificity

Applications

Price

Anti-Cytochrome P450 2C8 CYP2C8 Antibody

Human

ELISA, IF, IHC

$380
Cat # A01179
100ul

Anti-Cytochrome P450 2C8 CYP2C8 Rabbit Polyclonal Antibody

Human

ELISA, WB

$380
Cat # A01179-1
100ul

Anti-CYP2C8 Antibody Picoband®

1 Citations

Western blot analysis of CYP2C8 using anti-CYP2C8 antibody (A01179-2)

Flow Cytometry analysis of 293T cells using anti-CYP2C8 antibody (A01179-2)

Human, Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A01179-2
100 μg/vial

Cytochrome P450 2C8 (CYP2C8) (NM_000770) Human Over-expression Lysate

Human

$628
Cat # LS001558
20 µg, 100 µg

CYP2C8 Overview

Facts about Cytochrome P450 2C8.

CYP2C8 3D structure. Source: alphafold

Cytochrome P450 2C8 (CYP2C8)

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway.

It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids.

Gene Information

Human
Gene Name:	CYP2C8
Uniprot:	P10632
Entrez:	1558

Family

Belongs to:

cytochrome P450 family

Alternative Names

CPC8; CYPIIC8; cytochrome P450 2C8; Cytochrome P450 form 1; Cytochrome P450 IIC2; Cytochrome P450 MP-12; Cytochrome P450 MP-20; cytochrome P450, family 2, subfamily C, polypeptide 8; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8; EC 1.14.14.1; flavoprotein-linked monooxygenase; microsomal monooxygenase; MP-12/MP-20; P450 form 1; S-mephenytoin 4-hydroxylase; xenobiotic monooxygenase

Molecular Weight

Mass (kDA):
55.825 kDA

Genomic Context


Human

Location:	10q23.33
Sequence:	10; NC_000010.11 (95036772..95069497, complement)

Subcellular Localizations

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Diseases

Malignant Neoplasms
Neoplasms
Malignant Neoplasm Of Breast
Diabetes Mellitus
Diabetes Mellitus, Non-insulin-dependent
Malaria
Mammary Neoplasms
Malaria, Falciparum
Rhabdomyolysis
Hypertensive Disease
Carcinogenesis
Dysequilibrium Syndrome
Liver Carcinoma

Carcinoma
Hepatotoxicity
Inflammation
Hypoglycemia
Medication Reaction
Malignant Paraganglionic Neoplasm
Cardiovascular Diseases

Pathways

Transport
Excretion
Localization
Demethylation
Secretion
Conjugation
Cell Proliferation
Dna Repair
Pathogenesis
Drug Transport
Hypersensitivity
Translation
Vasodilation

Insulin Secretion
Angiogenesis
Drug Resistance
Cell Migration
Cell Differentiation
Cellular Localization
Tube Formation

PTMs

Hydroxylation
Oxidation
Demethylation
Cleavage
Phosphorylation
Carboxylation

Reduction
Acetylation
Deamination
Decarboxylation
Biotinylation
Methylation

Myristoylation

Research Areas

Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CYP2C8

References

PMID: 3500169 by Okino S.T., et al. Characterization of multiple human cytochrome P-450 1 cDNAs. The chromosomal localization of the gene and evidence for alternate RNA splicing.

PMID: 3697070 by Kimura S., et al. cDNA and amino acid sequences of two members of the human P450IIC gene subfamily.