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- Table of Contents
Cytochrome P450 2C8 Antibodies
AND CYP2C8 ELISA kits, Cytochrome P450 2C8 Proteins
Many biological assays use antibodies to detect Cytochrome P450 2C8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cytochrome P450 2C8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cytochrome P450 2C8 antibodies...
Designing a Western blot for Cytochrome P450 2C8? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CYP2C8 Western Blot GuideCYP2C8 Infographic by Boster Bio
All CYP2C8 Products
Product
Figures
Specificity
Applications
Price
Anti-CYP2C8 Antibody Picoband®
1 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A01179-2
100 μg/vial
Cat # A01179-2
100 μg/vial
Human
$628
Cat # LS001558
20 µg, 100 µg
Cat # LS001558
20 µg, 100 µg
CYP2C8 Overview
Facts about Cytochrome P450 2C8.
Cytochrome P450 2C8 (CYP2C8)
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway.
It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids.
Gene Information
| Human | |
|---|---|
| Gene Name: | CYP2C8 |
| Uniprot: | P10632 |
| Entrez: | 1558 |
Family
| Belongs to: |
|---|
| cytochrome P450 family |
Alternative Names
CPC8; CYPIIC8; cytochrome P450 2C8; Cytochrome P450 form 1; Cytochrome P450 IIC2; Cytochrome P450 MP-12; Cytochrome P450 MP-20; cytochrome P450, family 2, subfamily C, polypeptide 8; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8; EC 1.14.14.1; flavoprotein-linked monooxygenase; microsomal monooxygenase; MP-12/MP-20; P450 form 1; S-mephenytoin 4-hydroxylase; xenobiotic monooxygenase
Molecular Weight
Mass (kDA):
55.825 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q23.33 |
| Sequence: | 10; NC_000010.11 (95036772..95069497, complement) |
Subcellular Localizations
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Diabetes Mellitus
- Diabetes Mellitus, Non-insulin-dependent
- Malaria
- Mammary Neoplasms
- Malaria, Falciparum
- Rhabdomyolysis
- Hypertensive Disease
- Carcinogenesis
- Dysequilibrium Syndrome
- Liver Carcinoma
Pathways
- Transport
- Excretion
- Localization
- Demethylation
- Secretion
- Conjugation
- Cell Proliferation
- Dna Repair
- Pathogenesis
- Drug Transport
- Hypersensitivity
- Translation
- Vasodilation
PTMs
- Hydroxylation
- Oxidation
- Demethylation
- Cleavage
- Phosphorylation
- Carboxylation
Research Areas
- Lipid and Metabolism
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CYP2C8
bosterbio.com/bosterbio-gene-info-cards/CYP2C8
References
PMID: 3500169 by Okino S.T., et al. Characterization of multiple human cytochrome P-450 1 cDNAs. The chromosomal localization of the gene and evidence for alternate RNA splicing.
PMID: 3697070 by Kimura S., et al. cDNA and amino acid sequences of two members of the human P450IIC gene subfamily.