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- Table of Contents
Cytochrome P450 7B1 Antibodies
AND CYP7B1 ELISA kits, Cytochrome P450 7B1 Proteins
Many biological assays use antibodies to detect Cytochrome P450 7B1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cytochrome P450 7B1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cytochrome P450 7B1 antibodies...
Designing an IHC experiment for Cytochrome P450 7B1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the CYP7B1 IHC GuideCYP7B1 Infographic by Boster Bio
All CYP7B1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A03545-3
100 μg/vial
Cat # A03545-3
100 μg/vial
Human
ELISA
$480
Cat # EKC1922
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1922
1 kit, containing one 96-well plate and all necessary reagents
CYP7B1 Overview
Facts about Cytochrome P450 7B1.
Cytochrome P450 7B1 (CYP7B1)
Oxysterol 7alpha-hydroxylase that mediates formation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) from 25- hydroxycholesterol (PubMed:10588945). Plays a key role in cell placement and movement in lymphoid cells: 7-alpha,25- dihydroxycholesterol (7-alpha,25-OHC) acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of stem cells (By similarity).
.
Gene Information
| Human | |
|---|---|
| Gene Name: | CYP7B1 |
| Uniprot: | O75881 |
| Entrez: | 9420 |
Family
| Belongs to: |
|---|
| cytochrome P450 family |
Alternative Names
CBAS3; CP7B; Cytochrome P450 7B1; cytochrome P450, family 7, subfamily B, polypeptide 1; cytochrome P450, subfamily VIIB (oxysterol 7 alpha-hydroxylase), polypeptide 1,25-hydroxycholesterol 7-alpha-hydroxylase; EC 1.14.13.100; Oxysterol 7-alpha-hydroxylase; oxysterol 7alpha-hydroxylase; spastic paraplegia 5A (autosomal recessive); SPG5A
Molecular Weight
Mass (kDA):
58.256 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8q12.3 |
| Sequence: | 8; NC_000008.11 (64586575..64798737, complement) |
Tissue Specificity
Brain, testis, ovary, prostate, liver, colon, kidney, and small intestine.
Subcellular Localizations
Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.
Diseases
- Spastic Paraplegia, Hereditary
- Paraplegia
- Spastic Paraplegia
- Cholestasis
- Neoplasms
- Liver Diseases
- Inflammation
- Neurodegenerative Disorders
- Malignant Neoplasms
- Liver Carcinoma
- Muscle Spasticity
- Malignant Neoplasm Of Prostate
Pathways
- Pathogenesis
- Cholesterol Homeostasis
- Immune Response
- Excretion
- Secretion
- Gallstone Formation
- Lipid Homeostasis
- Transport
- Inflammatory Response
- Tissue Development
- Reverse Transcription
- Cognition
- Cell Proliferation
PTMs
- Hydroxylation
- Methylation
- Reduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CYP7B1
bosterbio.com/bosterbio-gene-info-cards/CYP7B1
References
PMID: 9802883 by Setchell K.D.R., et al. Identification of a new inborn error in bile acid synthesis: mutation of the oxysterol 7-alpha-hydroxylase gene causes severe neonatal liver disease.
PMID: 10588945 by Wu Z.L., et al. Structure and functions of human oxysterol 7alpha-hydroxylase cDNAs and gene CYP7B1.