CYP8B1 Antibodies

AND CYP8B1 ELISA kits, CYP8B1 Proteins

Many biological assays use antibodies to detect CYP8B1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CYP8B1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CYP8B1 antibodies...

We validate the specificity of these antibodies to CYP8B1 by testing them on tissues known to express CYP8B1 positively and negatively. Browse below to find the CYP8B1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CYP8B1 Infographic by Boster Bio

All CYP8B1 Products

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Anti-CYP8B1 Antibody

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Western Blot analysis of various cells using CYP8B1 Polyclonal Antibody

Western blot analysis of Cytochrome P450 8B1 Antibody

Western blot analysis of the lysates from HT-29 cells using Cytochrome P450 8B1 antibody

Human, Mouse

ELISA, IF, IHC, WB

$399
Cat # A05518-1
100μl

Anti-CYP8B1 Antibody

Western blot (WB) analysis of CYP8B1 polyclonal antibody at 1:500 dilution
Lane1:HEK293T cell lysate
Lane2:sp2/0 cell lysate
Lane3:PC12 cell lysate

Human, Mouse, Rat

IHC, WB

$405
Cat # A05518-2
100ul

CYP8B1 Overview

Facts about 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase.

CYP8B1 3D structure. Source: alphafold

7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (CYP8B1)

Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid.

Has a rather broad substrate specificity including a number of 7-alpha- hydroxylated C27 steroids. .

Gene Information

Human
Gene Name:	CYP8B1
Uniprot:	Q9UNU6
Entrez:	1582

Family

Belongs to:

cytochrome P450 family

Alternative Names

7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase

Molecular Weight

Mass (kDA):
58.068 kDA

Genomic Context


Human

Location:	3p22.1
Sequence:	3; NC_000003.12 (42872192..42875879, complement)

Tissue Specificity

Liver.

Subcellular Localizations

Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CYP8B1

References

PMID: 10051404 by Gaafvels M., et al. Structure and chromosomal assignment of the sterol 12alpha- hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P- 450 gene devoid of introns.