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- Table of Contents
Facts about Claudin-7.
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Human | |
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Gene Name: | CLDN7 |
Uniprot: | O95471 |
Entrez: | 1366 |
Belongs to: |
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claudin family |
CEPTRL2; claudin 7; claudin-1; Claudin7; Claudin-7; CLDN7; CLDN-7; clostridium perfringens enterotoxin receptor-like 2; CPETRL2
Mass (kDA):
22.418 kDA
Human | |
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Location: | 17p13.1 |
Sequence: | 17; NC_000017.11 (7259903..7263193, complement) |
Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane. Cell junction, tight junction. Co-localizes with EPCAM at the basolateral cell membrane and tight junction.
PMID: 14502431 by Zheng J.-Y., et al. Regulation of the expression of the prostate-specific antigen by claudin-7.
PMID: 12673207 by Kominsky S.L., et al. Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast.