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- Table of Contents
CXADR Antibodies
AND CXADR ELISA kits, CXADR Proteins
Many biological assays use antibodies to detect CXADR, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CXADR in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CXADR antibodies...
Designing a Western blot for CXADR? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CXADR Western Blot GuideCXADR Infographic by Boster Bio
All CXADR Products
Product
Figures
Specificity
Applications
Price
Human, Monkey, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A02747-1
100 µg/vial
Cat # A02747-1
100 µg/vial
Human
ELISA
$499
Cat # EK1730
96 wells/kit, with removable strips.
Cat # EK1730
96 wells/kit, with removable strips.
Human, Mouse, Rat
WB
$370
Cat # PA1852
100 μg/vial
Cat # PA1852
100 μg/vial
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M02747
100 μg
Cat # M02747
100 μg
CXADR Overview
Facts about Coxsackievirus and adenovirus receptor.
Coxsackievirus and adenovirus receptor (CXADR)
Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes.
The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases.
Gene Information
| Human | |
|---|---|
| Gene Name: | CXADR |
| Uniprot: | P78310 |
| Entrez: | 1525 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CAR10Coxsackievirus B-adenovirus receptor; CAR4/6; coxsackie virus and adenovirus receptor; coxsackie virus B receptor; coxsackievirus and adenovirus receptor; CVB3 binding protein; CVB3 BP; CVB3-binding protein; CXADR; HCAR; HCVADR
Molecular Weight
Mass (kDA):
40.03 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 21q21.1 |
| Sequence: | 21; NC_000021.9 (17512906..17636213) |
Tissue Specificity
Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy.
Subcellular Localizations
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Cell junction, adherens junction. In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions (PubMed:12297051). In airway epithelial cells localized to basolateral membrane but not to apical surface (PubMed:11316797).; [Isoform 3]: Secreted.; [Isoform 4]: Secreted.; [Isoform 5]: Secreted.
Diseases
- Tissue Adhesions
- Sudden Cardiac Death
- Ventricular Fibrillation
- Cardiac Fibrillation
- Cardiac Death
- Infarction
- Myocardial Infarction
- Cardiomyopathies
- Malignant Neoplasms
- Myocarditis
- Cardiac Arrhythmia
- Cardiomyopathy, Dilated
- Malignant Neoplasm Of Stomach
Pathways
- Cell Adhesion
- Pathogenesis
- Localization
- Methylation
- Translation
- Dna Methylation
- Immune Response
- Cell Growth
- Cell Fate Determination
PTMs
- Disulfide bond
- Glycoprotein
Research Areas
- Cell Biology
- Stem Cell Markers
- Virology, Bacteria and Parasites
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CXADR
bosterbio.com/bosterbio-gene-info-cards/CXADR
References
PMID: 9096397 by Tomko R.P., et al. HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses.
PMID: 9036860 by Bergelson J.M., et al. Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5.