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- Table of Contents
Facts about Coxsackievirus and adenovirus receptor.
The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases.
Human | |
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Gene Name: | CXADR |
Uniprot: | P78310 |
Entrez: | 1525 |
Belongs to: |
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No superfamily |
CAR10Coxsackievirus B-adenovirus receptor; CAR4/6; coxsackie virus and adenovirus receptor; coxsackie virus B receptor; coxsackievirus and adenovirus receptor; CVB3 binding protein; CVB3 BP; CVB3-binding protein; CXADR; HCAR; HCVADR
Mass (kDA):
40.03 kDA
Human | |
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Location: | 21q21.1 |
Sequence: | 21; NC_000021.9 (17512906..17636213) |
Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy.
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Cell junction, adherens junction. In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions (PubMed:12297051). In airway epithelial cells localized to basolateral membrane but not to apical surface (PubMed:11316797).; [Isoform 3]: Secreted.; [Isoform 4]: Secreted.; [Isoform 5]: Secreted.
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Using offsets to place markers is easy. After all other transformations, offsets are linear translations that are applied after the marker symbol layer has been transformed. To change the offset, navigate the Format Symbol pane to click on the Offset Distance heading. Under the Offset Distance heading, you will see the Offset X and Y properties. Offset Z is only available in 3D.
PMID: 9096397 by Tomko R.P., et al. HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses.
PMID: 9036860 by Bergelson J.M., et al. Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5.