Cytochrome P450 4V2 Antibodies

AND CYP4V2 ELISA kits, Cytochrome P450 4V2 Proteins

Many biological assays use antibodies to detect Cytochrome P450 4V2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cytochrome P450 4V2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cytochrome P450 4V2 antibodies...

We validate the specificity of these antibodies to Cytochrome P450 4V2 by testing them on tissues known to express CYP4V2 positively and negatively. Browse below to find the CYP4V2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for Cytochrome P450 4V2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the CYP4V2 IHC Guide

CYP4V2 Infographic by Boster Bio

All CYP4V2 Products

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Anti-Cytochrome P450 4V2 CYP4V2 Antibody

Immunohistochemical analysis of paraffin-embedded human Gastric adenocarcinoma

Human, Mouse, Rat

ELISA, IF, IHC, WB

$380
Cat # A05648-1
100ul

CYP4V2 Overview

Facts about Cytochrome P450 4V2.

CYP4V2 3D structure. Source: alphafold

Cytochrome P450 4V2 (CYP4V2)

Omega-hydroxylase that oxidizes medium-chain saturated fatty acids and polyunsaturated omega-3 fatty acids, and which plays a role in fatty acid and steroid metabolism in the eye (PubMed:19661213, PubMed:22772592). Catalyzes the omega- hydroxylation of medium-chain saturated fatty acids like laurate, myristate and palmitate in an NADPH-dependent pathway.

The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12) (PubMed:19661213). Acts as a polyunsaturated omega-3 fatty acids hydroxylase by mediating oxidation of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate (PubMed:22772592).

Gene Information

Human
Gene Name:	CYP4V2
Uniprot:	Q6ZWL3
Entrez:	285440

Family

Belongs to:

cytochrome P450 family

Alternative Names

BCD; CYP4AH1; cytochrome P450 4V2; cytochrome P450, family 4, subfamily V, polypeptide 2; EC 1.14; EC 1.14.14.1; FLJ18432; MGC43534

Molecular Weight

Mass (kDA):
60.724 kDA

Genomic Context


Human

Location:	4q35.1-q35.2
Sequence:	4; NC_000004.12 (186191567..186213463)

Tissue Specificity

Broadly expressed. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, retina, retinal pigment epithelium (RPE) and lymphocytes.

Subcellular Localizations

Endoplasmic reticulum membrane; Single-pass membrane protein.

Diseases

Dystrophy
Bietti Crystalline Corneoretinal Dystrophy
Hereditary Corneal Dystrophy
Retinal Degeneration
Retinal Diseases
Atrophy
Corneal Diseases
Blind Vision
Night Blindness
Retinal Dystrophies
Sclerosis
Venous Thrombosis
Stenosis

Deep Vein Thrombosis
Thrombosis
Malignant Neoplasms
Neoplasms
Abnormal Degeneration
Thrombophilia
Choroidal Sclerosis

Pathways

Pathogenesis
Localization
Coagulation
Lipid Homeostasis
Pigmentation
Reflex

PTMs

Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CYP4V2

References

PMID: 15042513 by Li A., et al. Bietti crystalline corneoretinal dystrophy is caused by mutations in the novel gene CYP4V2.

PMID: 19661213 by Nakano M., et al. Expression and characterization of CYP4V2 as a fatty acid omega- hydroxylase.