DDB1- and CUL4-associated factor 7 (DCAF7)

Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equal, the palatoquadrate.

The activity necessary for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity.