Protein DDI1 homolog 2 (Ddi2)

Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at'Leu-104', thereby promoting release of NFE2L1/NRF1 in the endoplasmic reticulum membrane. Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1.

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