ATP-dependent RNA helicase DDX3X (DDX3X)

The ATPase activity can be stimulated by various ribo- and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partly double-stranded DNA with a preference for 5'- single-stranded DNA overhangs.

Is involved in a number of steps of gene expression, such as transcription, mRNA maturation, mRNA export and translation. However, the specific mechanisms are not known and some functions may be specific for a subset of mRNAs.