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- Table of Contents
Facts about GATOR complex protein DEPDC5.
The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway. .
Human | |
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Gene Name: | DEPDC5 |
Uniprot: | O75140 |
Entrez: | 9681 |
Belongs to: |
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IML1 family |
DEP Domain-Containing Protein 5; DEP.5; DEPDC5; FFEVF; KIAA0645
Mass (kDA):
181.264 kDA
Human | |
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Location: | 22q12.2-q12.3 |
Sequence: | 22; NC_000022.11 (31753968..31908033) |
Expressed in developing and adult brain.
Cytoplasm, cytosol. Cytoplasm, perinuclear region. Lysosome membrane. Localization to lysosomes is amino acid-independent.
PMID: 15770670 by Seng T.J., et al. Complex chromosome 22 rearrangements in astrocytic tumors identified using microsatellite and chromosome 22 tile path array analysis.
PMID: 23723238 by Bar-Peled L., et al. A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.