KDM4A Antibodies

AND KDM4A ELISA kits, KDM4A Proteins

Many biological assays use antibodies to detect KDM4A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KDM4A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KDM4A antibodies...

We validate the specificity of these antibodies to KDM4A by testing them on tissues known to express KDM4A positively and negatively. Browse below to find the KDM4A antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for KDM4A? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the KDM4A IHC Guide

KDM4A Infographic by Boster Bio

All KDM4A Products

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Applications

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Anti-JHDM3A/JMJD2A/KDM4A Antibody Picoband®

1 Citations

Western blot analysis of JHDM3A/JMJD2A/KDM4A using anti-JHDM3A/JMJD2A/KDM4A antibody (A02850-1)

IHC analysis of JHDM3A/JMJD2A/KDM4A using anti-JHDM3A/JMJD2A/KDM4A antibody (A02850-1)

Human, Mouse, Rat

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A02850-1
100 μg/vial

Anti-KDM4A Monoclonal Antibody

All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature

Western blot analysis of KDM4A / JHDM3A / JMJD2A expression in (1) HEK293 cell lysate; (2) NIH3T3 cell lysate

Human, Mouse, Rat

IP, IHC, WB

$370
Cat # M02850
100 μl

Anti-JMJD2A KDM4A Antibody

Western blot analysis of JMJD2A in rat liver tissue lysate with JMJD2A antibody at (A) 1 and (B) 2 μg/mL

Immunohistochemistry of JMJD2A in rat liver tissue with JMJD2A antibody at 5 μg/mL

Human, Mouse, Rat

ELISA, IHC-P, WB

$481
Cat # A02850
0.1 mg

KDM4A (NM_014663) Human Over-expression Lysate

Human

$628
Cat # LS009682
20 µg, 100 µg

KDM4A (NM_014663) Human Recombinant Protein

Coomassie blue staining of purified KDM4A protein

$1062
Cat # PROTO75164
20 µg

KDM4A Overview

Facts about Lysine-specific demethylase 4A.

KDM4A 3D structure. Source: alphafold

Lysine-specific demethylase 4A (KDM4A)

Histone demethylase that specifically demethylates'Lys- 9' and'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:26741168). Doesn't demethylate histone H3'Lys-4', H3'Lys-27' nor H4'Lys-20'.

Demethylates trimethylated H3'Lys-9' and H3'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.

Gene Information

Human
Gene Name:	KDM4A
Uniprot:	O75164
Entrez:	9682

Family

Belongs to:

JHDM3 histone demethylase family

Alternative Names

EC 1.14.11; EC 1.14.11.-; JHDM3A; JHDM3AJMJD2; JmjC domain-containing histone demethylation protein 3A; JMJD2; JMJD2A; JMJD2Alysine-specific demethylase 4A; jumonji domain containing 2; jumonji domain containing 2A; Jumonji domain-containing protein 2A; KDM4A; KIAA0677jumonji C domain-containing histone demethylase 3A; Lysine (K)specific Demethylase 4A; Lysine (K)-specific Demethylase 4A

Molecular Weight

Mass (kDA):
120.662 kDA

Genomic Context


Human

Location:	1p34.2-p34.1
Sequence:	1; NC_000001.11 (43650149..43705518)

Tissue Specificity

Ubiquitous.

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Neoplasms
Mammary Neoplasms
Cell Transformation, Neoplastic
Malignant Neoplasm Of Breast
Neoplasm Invasiveness
Carcinoma
Cell Invasion
Cardiac Hypertrophy
Hypertrophy
Colonic Neoplasms
Malignant Neoplasm Of Lung
Left Ventricular Hypertrophy

Osteosarcoma
Malignant Neoplasm Of Prostate
Retinoblastoma
Leukemia
Autoimmunity
Instabilities, Chromosomal
Neoplasm Metastasis

Interacting Proteins

ERG
HIST1H3A
HIST1H4A
HIST3H3

Pathways

Methylation
Demethylation
Histone Methylation
Cell Cycle
Cell Proliferation
Regulation Of Gene Expression
Gene Silencing
Dna Repair
Heterochromatin Organization
Cell Migration
Histone Modification
Oncogenesis
Histone Demethylation

Histone H3 Acetylation
Dna Replication
S Phase
Cell Growth
Pathogenesis
Cellular Senescence
Oxidative Demethylation

PTMs

Methylation
Demethylation
Acetylation

Ubiquitination
Hydroxylation
Dephosphorylation

Research Areas

Epigenetics

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KDM4A

References

PMID: 15927959 by Gray S.G., et al. Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein.

PMID: 16024779 by Zhang D., et al. JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2).