Lysine-specific demethylase 4A (KDM4A)

Histone demethylase that specifically demethylates'Lys- 9' and'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:26741168). Doesn't demethylate histone H3'Lys-4', H3'Lys-27' nor H4'Lys-20'.

Demethylates trimethylated H3'Lys-9' and H3'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.