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- Table of Contents
Facts about Protein diaphanous homolog 1.
Required for cytokinesis, and transcriptional activation of the serum response factor (By similarity). DFR proteins bunch Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity).
| Human | |
|---|---|
| Gene Name: | DIAPH1 |
| Uniprot: | O60610 |
| Entrez: | 1729 |

| Belongs to: |
|---|
| formin homology family |

DIA1; diaphanous homolog 1 (Drosophila); hDIA1; homolog) 1; LFHL1FLJ25265
Mass (kDA):
141.347 kDA

| Human | |
|---|---|
| Location: | 5q31.3 |
| Sequence: | 5; NC_000005.10 (141515016..141619055, complement) |
Expressed in brain, heart, placenta, lung, kidney, pancreas, liver, skeletal muscle and cochlea. Expressed in platelets (PubMed:26912466).
Cell membrane. Cell projection, ruffle membrane. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Nucleus. Membrane ruffles, especially at the tip of ruffles, of motile cells.






PMID: 9360932 by Lynch E.D., et al. Nonsyndromic deafness DFNA1 associated with mutation of a human homolog of the Drosophila gene diaphanous.
PMID: 16887337 by Morita K., et al. HAN11 binds mDia1 and controls GLI1 transcriptional activity.