DIO2 Antibodies

AND DIO2 ELISA kits, DIO2 Proteins

Many biological assays use antibodies to detect DIO2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DIO2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DIO2 antibodies...

We validate the specificity of these antibodies to DIO2 by testing them on tissues known to express DIO2 positively and negatively. Browse below to find the DIO2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for DIO2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the DIO2 Western Blot Guide

DIO2 Infographic by Boster Bio

All DIO2 Products

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Specificity

Applications

Price

Anti-DIO2 Antibody Picoband®

Western blot analysis of DIO2 using anti-DIO2 antibody (A02249-2)

Rat

$370
Cat # A02249-2
100 μg/vial

Anti-DIO2 Antibody (Center)

Human, Mouse

Flow Cytometry, IHC-P, WB

$299
Cat # A02249-1
80 µl

DIO2 Overview

Facts about Type II iodothyronine deiodinase.

Type II iodothyronine deiodinase (DIO2)

Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for supplying the brain with appropriate levels of T3 during the crucial period of development.

Gene Information

Human
Gene Name:	DIO2
Uniprot:	Q92813
Entrez:	1734

Family

Belongs to:

iodothyronine deiodinase family

Alternative Names

5DII; D2; deiodinase, iodothyronine, type II; DIOII; EC 1.97.1; EC 1.97.1.10; ITDI2; SelY; TXDI2thyroxine deiodinase, type II; Type 2 DI; type 2 iodothyronine deiodinase; type II iodothyronine deiodinase; type-II 5'deiodinase; Type-II 5'-deiodinase

Molecular Weight

Mass (kDA):
30.552 kDA

Genomic Context


Human

Location:	14q31.1
Sequence:	14; NC_000014.9 (80197526..80231057, complement)

Tissue Specificity

Heart, skeletal muscle, placenta, fetal brain and several regions of the adult brain.

Subcellular Localizations

Membrane; Single-pass membrane protein.

Diseases

Pituitary Diseases
Obesity
Hypothyroidism
Insulin Resistance
Degenerative Polyarthritis
Dysequilibrium Syndrome
Diabetes Mellitus
Neoplasms
Hypertrophy
Carcinoma
Diabetes Mellitus, Non-insulin-dependent

Malignant Neoplasms
Osteoarthritis Of Hip
Atrophy
Thyroid Neoplasm
Thyroid Diseases
Thyrotoxicosis

Pathways

Secretion
Brain Development
Transport
Pathogenesis
Cell Proliferation
Cell Cycle
Cell Adhesion
Gluconeogenesis
Ossification
Energy Homeostasis
Dna Replication
Innervation
Aging

Inflammatory Response
Response To Cold
Photoperiodism
Localization
Chondrocyte Differentiation
Histone Phosphorylation
Glucose Homeostasis

PTMs

Deiodination
Ubiquitination
Phosphorylation

Carboxylation
Acetylation
Oxidation

Prenylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DIO2

References

PMID: 8755651 by Croteau W., et al. Cloning of the mammalian type II iodothyronine deiodinase. A selenoprotein differentially expressed and regulated in human and rat brain and other tissues.

PMID: 9837913 by Buettner C., et al. The 3'-untranslated region of human type 2 iodothyronine deiodinase mRNA contains a functional selenocysteine insertion sequence element.