DLAT Antibodies

AND DLAT ELISA kits, DLAT Proteins

Many biological assays use antibodies to detect DLAT, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DLAT in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DLAT antibodies...

We validate the specificity of these antibodies to DLAT by testing them on tissues known to express DLAT positively and negatively. Browse below to find the DLAT antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for DLAT? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the DLAT Western Blot Guide

DLAT Infographic by Boster Bio

All DLAT Products

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Specificity

Applications

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Anti-DLAT Antibody Picoband®

2 Citations

Western blot analysis of DLAT using anti-DLAT antibody (A04469-2)

IHC analysis of DLAT using anti-DLAT antibody (A04469-2)

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A04469-2
100 μg/vial

Anti-DLAT Rabbit Monoclonal Antibody

1 Citations

All lanes use the Antibody at 1:1W dilution for 1 hour at room temperature

Immunofluorescent analysis using the Antibody at 1:50 dilution

Human, Mouse, Rat

Flow Cytometry, IP, IF, IHC, ICC, WB

$370
Cat # M04469-1
100 μl/vial

Pyruvate Dehydrogenase E2 (DLAT) (NM_001931) Human Over-expression Lysate

Human

$628
Cat # LS001737
20 µg, 100 µg

DLAT Overview

Facts about Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial.

DLAT 3D structure. Source: alphafold

Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (DLAT)

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. .

Gene Information

Human
Gene Name:	DLAT
Uniprot:	P10515
Entrez:	1737

Family

Belongs to:

2-oxoacid dehydrogenase family

Alternative Names

70 kDa mitochondrial autoantigen of primary biliary cirrhosis; dihydrolipoamide S-acetyltransferase; DLTA; E2 component of pyruvate dehydrogenase complex; EC 2.3.1; M2 antigen complex 70 kDa subunit; PBC; PDC-E2EC 2.3.1.12; PDCE2mitochondrial

Molecular Weight

Mass (kDA):
68.997 kDA

Genomic Context


Human

Location:	11q23.1
Sequence:	11; NC_000011.10 (112025408..112064404)

Subcellular Localizations

Mitochondrion matrix.

Diseases

Liver Cirrhosis
Biliary Cirrhosis
Primary Biliary Cirrhosis
Autoimmune Reaction
Autoimmune Diseases
Malignant Neoplasms
Cholangitis
Lymphoma
Neoplasms
Acidosis
Acidosis, Lactic
Inflammation

Pyruvate Dehydrogenase Complex Deficiency Disease
Autoimmunity
Liver Diseases
Ataxia
Hepatitis
Muscle Hypotonia
Arthritis

Interacting Proteins

PDHB
PDK3
SIRT4

Pathways

Cell Proliferation
Pathogenesis
Transport
Cell Death
Protein Phosphorylation
Tricarboxylic Acid Cycle
Electron Transport
Mitosis
Cytokine Secretion
Virulence
Tropism
Localization
Cytokine Production

Gliogenesis
Protein Folding
Regulation Of Cell Proliferation
Feeding Behavior
Cell Recognition
Granuloma Formation
Excretion

PTMs

Phosphorylation

Research Areas

Core ESC-Like Genes
Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DLAT

References

PMID: 3174635 by Coppel R.L., et al. Primary structure of the human M2 mitochondrial autoantigen of primary biliary cirrhosis: dihydrolipoamide acetyltransferase.

PMID: 3191998 by Thekkumkara T.J., et al. Nucleotide sequence of a cDNA for the dihydrolipoamide acetyltransferase component of human pyruvate dehydrogenase complex.