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Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in modulating cell proliferation, maintenance of epithelial polarity, epithelial- mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360).
|Sequence:||10; NC_000010.11 (77790787..77926755, complement)|
Highly expressed in normal breast tissues and low-grade breast cancer tissues (at protein level) (PubMed:28169360). Highly expressed in the placenta and prostate. Expressed at a lower level in the thyroid, spinal cord, trachea, adrenal gland, skeletal muscle, pancreas, heart, brain, liver and kidney. A short splice product shows more limited expression, being absent from at least the brain.
Cell junction. Cell membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic density. Cytoplasm, cytoskeleton, cilium basal body. Localized at sites of cell-cell contact.