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Disks large homolog 5 Antibodies
AND DLG5 ELISA kits, Disks large homolog 5 Proteins
Many biological assays use antibodies to detect Disks large homolog 5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Disks large homolog 5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Disks large homolog 5 antibodies...
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DLG5 Overview
Facts about Disks large homolog 5.
Disks large homolog 5 (DLG5)
Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714).
Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in modulating cell proliferation, maintenance of epithelial polarity, epithelial- mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360).
Gene Information
| Human | |
|---|---|
| Gene Name: | DLG5 |
| Uniprot: | Q8TDM6 |
| Entrez: | 9231 |
Family
| Belongs to: |
|---|
| MAGUK family |
Alternative Names
discs, large homolog 5 (Drosophila); KIAA0583large (Drosophila) homolog 5; LP-DLG
Molecular Weight
Mass (kDA):
213.868 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q22.3 |
| Sequence: | 10; NC_000010.11 (77790787..77926755, complement) |
Tissue Specificity
Highly expressed in normal breast tissues and low-grade breast cancer tissues (at protein level) (PubMed:28169360). Highly expressed in the placenta and prostate. Expressed at a lower level in the thyroid, spinal cord, trachea, adrenal gland, skeletal muscle, pancreas, heart, brain, liver and kidney. A short splice product shows more limited expression, being absent from at least the brain.
Subcellular Localizations
Cell junction. Cell membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic density. Cytoplasm, cytoskeleton, cilium basal body. Localized at sites of cell-cell contact.
Diseases
- Crohn Disease
- Inflammatory Bowel Diseases
- Intestinal Diseases
- Colitis
- Ulcerative Colitis
- Ulcer
- Inflammation
- Malignant Neoplasms
- Dysequilibrium Syndrome
- Neoplasms
- Arthritis
- Tissue Adhesions
Interacting Proteins
- Tgfbr1
- Tgfbr2
Pathways
- Pathogenesis
- Immune Response
- Localization
- Cell Migration
- Inflammatory Response
- Transport
- Cell Adhesion
- Cell Proliferation
- Programmed Cell Death
- Cytokinesis
- Cell Division
- Cell Cycle
- Cell Death
PTMs
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DLG5
bosterbio.com/bosterbio-gene-info-cards/DLG5
References
PMID: 9738934 by Nakamura H., et al. Identification of a novel human homolog of the Drosophila dlg, P-dlg, specifically expressed in the gland tissues and interacting with p55.
PMID: 11876824 by Shah G., et al. The cloning, genomic organization and tissue expression profile of the human DLG5 gene.