DnaJ homolog subfamily C member 10 (DNAJC10)

Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR.

Also involved in endoplasmic reticulum-associated degradation (ERAD) by decreasing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its action, not for the disulfide reductase activity, but to facilitate the launch of DNAJC10 from its substrate.