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- Table of Contents
Dynamin-2 Antibodies
AND DNM2 ELISA kits, Dynamin-2 Proteins
Many biological assays use antibodies to detect Dynamin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Dynamin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Dynamin-2 antibodies...
Designing a Western blot for Dynamin-2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the DNM2 Western Blot GuideDNM2 Infographic by Boster Bio
All DNM2 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, WB
$370
Cat # A01629-3
100 μg/vial
Cat # A01629-3
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01629
100 μl
Cat # M01629
100 μl
DNM2 Overview
Facts about Dynamin-2.
Dynamin-2 (DNM2)
Microtubule-associated force-producing protein involved in producing microtubule bundles and can bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity).
Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis (PubMed:12498685).
Gene Information
| Human | |
|---|---|
| Gene Name: | DNM2 |
| Uniprot: | P50570 |
| Entrez: | 1785 |
Family
| Belongs to: |
|---|
| TRAFAC class dynamin-like GTPase superfamily |
Alternative Names
CMTDI1CMT2M; CMTDIBdynamin II; DI-CMTB; DYN2EC 3.6.5.5; dynamin 2; dynamin-2; DYNII
Molecular Weight
Mass (kDA):
98.064 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.2 |
| Sequence: | 19; NC_000019.10 (10718053..10831910) |
Tissue Specificity
Ubiquitously expressed.
Subcellular Localizations
Cytoplasm. Cytoplasm, cytoskeleton. Cell junction. Membrane, clathrin-coated pit. Cell junction, synapse, postsynaptic density. Cell junction, synapse. Midbody. Cell projection, phagocytic cup. Cytoplasmic vesicle, phagosome membrane; Peripheral membrane protein. Colocalizes with CTTN at the basis of filopodia in hippocampus neuron growth zones (By similarity). Microtubule-associated. Also found in the postsynaptic density of neuronal cells. Co-localizes with PIK3C3 and RAB5A to the nascent phagosome (By similarity).
Diseases
- Myopathy
- Congenital Structural Myopathy
- Charcot-marie-tooth Disease
- Weakness
- Congenital Myopathy (disorder)
- Muscle Weakness
- Peripheral Neuropathy
- Blepharoptosis
- Ophthalmoplegia
- Atrophy
- External Ophthalmoplegia
- Nervousness
Interacting Proteins
- AHI1
- CTTN
- GRB2
- ITSN1
- MYO1E
- NME2
- PACSIN2
- SH3BP4
- SH3GL2
- SH3KBP1
Pathways
- Endocytosis
- Clathrin-mediated Endocytosis
- Transport
- Localization
- Myelination
- Pathogenesis
- Rna Interference
- Autophagy
- Spermatogenesis
- Nuclear Transport
- Myelin Maintenance
- Translation
- Interphase
PTMs
Research Areas
- Apoptosis
- Membrane Trafficking and Chaperones
- Neuronal Cell Markers
- Neuroscience
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DNM2
bosterbio.com/bosterbio-gene-info-cards/DNM2
References
PMID: 7590285 by Diatloff-Zito C., et al. Isolation of an ubiquitously expressed cDNA encoding human dynamin II, a member of the large GTP-binding protein family.
PMID: 11583995 by Okamoto P.M., et al. Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton.