Dysbindin (DTNBP1)

Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complicated, the BLOC-1 complicated is required to target membrane protein cargos into vesicles constructed at cell bodies for delivery into neurites and nerve terminals.

The BLOC-1 complicated, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complicated to facilitate the transfer of TYRP1 independent of AP-3 function.