DVL1 Antibodies

AND DVL1 ELISA kits, DVL1 Proteins

Many biological assays use antibodies to detect DVL1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DVL1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DVL1 antibodies...

We validate the specificity of these antibodies to DVL1 by testing them on tissues known to express DVL1 positively and negatively. Browse below to find the DVL1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DVL1 Infographic by Boster Bio

All DVL1 Products

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Anti-DVL1 Antibody

Western blot analysis of extracts of Mouse kidney, using DVL1 antibody at 1:1000 dilution

Immunohistochemistry of paraffin-embedded rat testis using DVL1 antibody at dilution of 1:100

Immunohistochemistry of paraffin-embedded mouse testis using DVL1 antibody at dilution of 1:100

Human, Mouse, Rat

IF, IHC, ICC, WB

$405
Cat # A03533
100ul

DVL1 (NM_182779) Human Over-expression Lysate

DVL1 Human Over-expression Lysates NM_004421

Human

$628
Cat # LS001855
20 µg, 100 µg

Anti-DVL1 Antibody

Human, Mouse, Rat

ELISA, IHC, WB

$370
Cat # A03533-3
100 μl/vial

DVL1 Overview

Facts about Segment polarity protein dishevelled homolog DVL-1.

DVL1 3D structure. Source: alphafold

Segment polarity protein dishevelled homolog DVL-1 (DVL1)

Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling.

Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling.

Gene Information

Human
Gene Name:	DVL1
Uniprot:	O14640
Entrez:	1855

Family

Belongs to:

DSH family

Alternative Names

dishevelled 1 (homologous to Drosophila dsh); dishevelled, dsh homolog 1 (Drosophila); Dishevelled1; Dishevelled-1; DSH homolog 1; Dsh; DVL; DVL1; DVL1L1; MGC54245; segment polarity protein dishevelled homolog DVL-1

Molecular Weight

Mass (kDA):
75.187 kDA

Genomic Context


Human

Location:	1p36.33
Sequence:	1; NC_000001.11 (1335278..1349418, complement)

Subcellular Localizations

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol. Cytoplasmic vesicle. Localizes at the cell membrane upon interaction with frizzled family members.

Diseases

Malignant Neoplasms
Neoplasms
Carcinoma
Malignant Neoplasm Of Breast
Mammary Neoplasms
Malignant Neoplasm Of Lung
Carcinogenesis
Crest Syndrome
Neoplasm Metastasis
Lung Neoplasms
Malignant Paraganglionic Neoplasm
Carcinoma, Lobular
Neuroblastoma

Non-small Cell Lung Carcinoma
Ductal Breast Carcinoma
Nervousness
Prostatic Neoplasms
Congenital Heart Defects
Invasive Lobular Breast Carcinoma
Malignant Neoplasm Of Ovary

Interacting Proteins

APC
Axin1
CSNK1E
Cxxc4
DVL3

LRRK2
SCYL2
SIRT1
TFDP1
WWTR1

Pathways

Convergent Extension
Localization
Cell Proliferation
Neural Tube Closure
Axon Guidance
Segmentation
Tube Closure
Prepulse Inhibition
Regulation Of Dendrite Development
Hyperphosphorylation
Transposition
Fruit Development
Programmed Cell Death

Lung Development
Taste Perception
Chondrocyte Proliferation
Reverse Transcription
Cell Cycle
Cell Motility
Transdifferentiation

PTMs

Phosphorylation

Methylation

Research Areas

Signal Transduction
Wnt Signaling Pathway

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DVL1

References

PMID: 9192851 by Semenov M.V., et al. Human dishevelled genes constitute a DHR-containing multigene family.

PMID: 11742073 by Chen W., et al. beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins.