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- Table of Contents
DVL1 Antibodies
AND DVL1 ELISA kits, DVL1 Proteins
Many biological assays use antibodies to detect DVL1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DVL1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DVL1 antibodies...
Designing an IHC experiment for DVL1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the DVL1 IHC GuideDVL1 Infographic by Boster Bio
All DVL1 Products
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DVL1 Overview
Facts about Segment polarity protein dishevelled homolog DVL-1.
Segment polarity protein dishevelled homolog DVL-1 (DVL1)
Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling.
Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling.
Gene Information
| Human | |
|---|---|
| Gene Name: | DVL1 |
| Uniprot: | O14640 |
| Entrez: | 1855 |
Family
| Belongs to: |
|---|
| DSH family |
Alternative Names
dishevelled 1 (homologous to Drosophila dsh); dishevelled, dsh homolog 1 (Drosophila); Dishevelled1; Dishevelled-1; DSH homolog 1; Dsh; DVL; DVL1; DVL1L1; MGC54245; segment polarity protein dishevelled homolog DVL-1
Molecular Weight
Mass (kDA):
75.187 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p36.33 |
| Sequence: | 1; NC_000001.11 (1335278..1349418, complement) |
Subcellular Localizations
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol. Cytoplasmic vesicle. Localizes at the cell membrane upon interaction with frizzled family members.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Malignant Neoplasm Of Lung
- Carcinogenesis
- Crest Syndrome
- Neoplasm Metastasis
- Lung Neoplasms
- Malignant Paraganglionic Neoplasm
- Carcinoma, Lobular
- Neuroblastoma
Interacting Proteins
- APC
- Axin1
- CSNK1E
- Cxxc4
- DVL3
- LRRK2
- SCYL2
- SIRT1
- TFDP1
- WWTR1
Pathways
- Convergent Extension
- Localization
- Cell Proliferation
- Neural Tube Closure
- Axon Guidance
- Segmentation
- Tube Closure
- Prepulse Inhibition
- Regulation Of Dendrite Development
- Hyperphosphorylation
- Transposition
- Fruit Development
- Programmed Cell Death
PTMs
- Phosphorylation
Research Areas
- Signal Transduction
- Wnt Signaling Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DVL1
bosterbio.com/bosterbio-gene-info-cards/DVL1
References
PMID: 9192851 by Semenov M.V., et al. Human dishevelled genes constitute a DHR-containing multigene family.
PMID: 11742073 by Chen W., et al. beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins.