Protein ECT2 (ECT2)

Guanine nucleotide exchange factor (GEF) which catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42.

Part of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling needed for the myosin contractile ring formation throughout the cell cycle cytokinesis. Regulates the translocation of RHOA in the central spindle into the equatorial region.