Eukaryotic translation initiation factor 3 subunit C (EIF3C)

Part of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for many steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC).

The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and then prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632).