Eukaryotic initiation factor 4A-I (EIF4A1)

ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the present version of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs that's necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.

.