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- Table of Contents
EIF4EBP1 Antibodies
AND EIF4EBP1 ELISA kits, EIF4EBP1 Proteins
Many biological assays use antibodies to detect EIF4EBP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with EIF4EBP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop EIF4EBP1 antibodies...
Designing a Western blot for EIF4EBP1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the EIF4EBP1 Western Blot GuideEIF4EBP1 Infographic by Boster Bio
All EIF4EBP1 Products
Product
Figures
Specificity
Applications
Price
Anti-EIF4EBP1 Antibody Picoband®
3 Citations
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # A00968-1
100 μg/vial
Cat # A00968-1
100 μg/vial
Anti-eIF4EBP1/4Ebp1 Rabbit Monoclonal Antibody
1 Citations
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00968
100 μl
Cat # M00968
100 μl
Human
WB
$370
Cat # M00968T70
100 µl/vial
Cat # M00968T70
100 µl/vial
Human, Mouse
IHC, WB
$370
Cat # M00968T46T32
100 µl/vial
Cat # M00968T46T32
100 µl/vial
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00968-1
20μL, 40μL, 100μL, 200μL
Cat # M00968-1
20μL, 40μL, 100μL, 200μL
Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A00968T69
100ul
Cat # A00968T69
100ul
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A00968S65-1
100ul
Cat # A00968S65-1
100ul
Human, Mouse, Rat
ELISA
$540
Cat # EKC2346
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2346
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2345
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2345
1 kit, containing two 96-well plates and all necessary reagents
Mouse, Rat
ELISA
$540
Cat # EKC2013
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2013
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2012
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2012
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1006
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1006
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA, IF, IHC
$380
Cat # A00968T70
100ul
Cat # A00968T70
100ul
Bovine, Chicken, Guinea pig, Human, Monkey, Mouse, Rabbit, Rat, Sheep, Fish
ELISA, IF, IHC, WB
$380
Cat # A00968T37-1
100ul
Cat # A00968T37-1
100ul
EIF4EBP1 Overview
Facts about Eukaryotic translation initiation factor 4E-binding protein 1.
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, resulting in initiation of translation.
Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. .
Gene Information
| Human | |
|---|---|
| Gene Name: | EIF4EBP1 |
| Uniprot: | Q13541 |
| Entrez: | 1978 |
Family
| Belongs to: |
|---|
| eIF4E-binding protein family |
Alternative Names
4EBP1; 4E-BP1; eIF4E-binding protein 1; EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1,4EBP1,4E-BP1BP-1; eukaryotic translation initiation factor 4E-binding protein 1; PHAS-I; PHAS-IMGC4316; Phosphorylated heat- and acid-stable protein regulated by insulin 1
Molecular Weight
Mass (kDA):
12.58 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8p11.23 |
| Sequence: | 8; NC_000008.11 (38030534..38060365) |
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Hypertrophy
- Diabetes Mellitus
- Cell Transformation, Neoplastic
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Atrophy
- Tuberous Sclerosis
- Sclerosis
- Muscular Atrophy
Interacting Proteins
- AGO2
- EIF4E
- MTOR
- Mtor
- REL
- RPTOR
- TCF4
Pathways
- Translation
- Cell Growth
- Cell Cycle
- Cell Proliferation
- Cell Death
- Hyperphosphorylation
- Pathogenesis
- Regulation Of Translation
- Muscle Atrophy
- Autophagy
- Angiogenesis
- Cell Cycle Arrest
- Transport
PTMs
- Phosphorylation
- Dephosphorylation
- Cleavage
- Ubiquitination
- Methylation
- Demethylation
Research Areas
- Cancer
- Core ESC-Like Genes
- DNA Repair
- DNA replication, Transcription, Translation and Splicing
- Lipid and Metabolism
- mTOR Pathway
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EIF4EBP1
bosterbio.com/bosterbio-gene-info-cards/EIF4EBP1
References
PMID: 7935836 by Pause A., et al. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function.
PMID: 8521827 by Haghighat A., et al. Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor- 4E.
3 Publications of Boster EIF4EBP1 Antibodies & ELISA Kits
- PubMed ID: 10.1371/journal.pone.0258817, PKI-587 enhances radiosensitization of hepatocellular carcinoma by inhibiting th...
- PubMed ID: 10.1007/s10495-017-1391-1, Multi-targeted therapy of everolimus in Kaposi’s sarcoma associated herpes vir...
- PubMed ID: 33982772, Xu R,Zhang Y,Li A,Ma Y,Cai W,Song L,Xie Y,Zhou S,Cao W,Tang X.LY‑294002 enhanc...
*More publications can be found for each product on its corresponding product page