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- Table of Contents
EIF5A Antibodies
AND EIF5A ELISA kits, EIF5A Proteins
Many biological assays use antibodies to detect EIF5A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with EIF5A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop EIF5A antibodies...
Designing a Western blot for EIF5A? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the EIF5A Western Blot GuideEIF5A Infographic by Boster Bio
All EIF5A Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01727-4
100 μg/vial
Cat # A01727-4
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A01727-3
100 μg/vial
Cat # A01727-3
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M01727
100 μl
Cat # M01727
100 μl
EIF5A Overview
Facts about Eukaryotic translation initiation factor 5A-1.
Eukaryotic translation initiation factor 5A-1 (EIF5A)
Has an important role at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity.
With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF- alpha-mediated apoptosis.
Gene Information
| Human | |
|---|---|
| Gene Name: | EIF5A |
| Uniprot: | P63241 |
| Entrez: | 1984 |
Family
| Belongs to: |
|---|
| eIF-5A family |
Alternative Names
eIF4D; eIF-4D; eIF5A; EIF-5A; EIF5A1; eIF-5A1; eIF-5A-1; eIF5AI; Eukaryotic initiation factor 5A isoform 1; eukaryotic initiation factor 5A; eukaryotic translation initiation factor 5A; eukaryotic translation initiation factor 5A-1; MGC104255; MGC99547; Rev-binding Factor
Molecular Weight
Mass (kDA):
16.832 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17p13.1 |
| Sequence: | 17; NC_000017.11 (7306999..7312463) |
Tissue Specificity
Expressed in umbilical vein endothelial cells and several cancer cell lines (at protein level).
Subcellular Localizations
Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex. Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Malaria
- Inflammation
- Malignant Paraganglionic Neoplasm
- Neoplasm Metastasis
- Diabetes Mellitus
- Liver Carcinoma
- Diabetes Mellitus, Non-insulin-dependent
- Hiv Infections
- Cell Invasion
- Hyperplasia
Interacting Proteins
- CRX
- DHPS
- MEOX2
- REL
Pathways
- Translation
- Cell Proliferation
- Cell Growth
- Cell Cycle
- Localization
- Cell Death
- Transport
- Nuclear Export
- Induction Of Apoptosis
- Cell Differentiation
- Cell Cycle Arrest
- Regulation Of Cell Proliferation
- Rna Interference
PTMs
- Hydroxylation
- Phosphorylation
- Acetylation
- Reduction
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EIF5A
bosterbio.com/bosterbio-gene-info-cards/EIF5A
References
PMID: 2492279 by Smit-Mcbride Z., et al. Sequence determination and cDNA cloning of eukaryotic initiation factor 4D, the hypusine-containing protein.
PMID: 8253832 by Ruhl M., et al. Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type 1 Rev activation domain mediating trans- activation.