ELAV-like protein 2 Antibodies

ELAV-like protein 2 (ELAVL2)

Binds RNA.

Seems to recognize that a GAAA motif.

Can bind to its 3'-UTR, the FOS 3'-UTR and the ID 3'-UTR. .

Gene Information

Human
Gene Name:	ELAVL2
Uniprot:	Q12926
Entrez:	1993

Family

Belongs to:
RRM elav family

Alternative Names

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B); ELAV-like neuronal protein 1; ELAV-like protein 2; HELN1; HEL-N1; Hu-antigen B; HuB; HUBELAV (embryonic lethal, abnormal vision, Drosophila)-like 2; Nervous system-specific RNA-binding protein Hel-N1

Molecular Weight

Mass (kDA):
39.504 kDA

Genomic Context

Human
Location:	9p21.3
Sequence:	9; NC_000009.12 (23690099..23850708, complement)

Tissue Specificity

Brain; neural-specific.

Diseases

• Malignant Neoplasms
• Visual Impairment
• Nervousness
• Neoplasms
• Small Cell Carcinoma Of Lung
• Malignant Neoplasm Of Lung
• Lung Neoplasms
• Carcinoma
• Neuroblastoma
• Nervous System Disorder
• Stomach Neoplasms
• Adenocarcinoma

• Non-small Cell Lung Carcinoma
• Monosomy
• Leukemia
• Neuroendocrine Tumors
• Neoplasm Metastasis
• Malnutrition
• Embryonal Carcinoma

Pathways

• Translation
• Cell Cycle
• Localization
• Cell Growth
• Neurogenesis
• Cell Proliferation
• Cell Differentiation
• Pathogenesis
• Transport
• Immune Response
• Virulence
• Cell Maturation
• Rna Stabilization

• Reverse Transcription
• Stem Cell Proliferation
• Mrna Stabilization
• Epithelial Cell Differentiation
• Regulation Of Mrna Stability
• Oogenesis
• Translational Initiation

PTMs

• Methylation

Research Areas

• Neuroscience
• Vision

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ELAVL2

Best Uses Of The ELAVL2 Marker

The ELAVL2 protein has a His tag attached. It is derived from E. coli. The ELAVL2 proteins can be stored at a temperature between +2 and -20degC for a week or -20degC up to -80degC long term storage. It is also suitable to be frozen repeatedly. All types of scientists can use the ELAVL2 proteins.

Steven Boster

The ELOVL2 marker is a promising biomarker to detect aging. Its methylation level changes with age. ELOVL2 expression correlates closely with single-copy status, age at diagnosis and low-risk tumor transcriptional profile. This marker has many other benefits, including the ability to detect invasive skin cancers and predict their progression.

ELAVL2Marker

ELAVL2 is a new biomarker that has several uses in the research field. Its primary function involves detecting abnormalities in karyopherin's nuclear transport protein family. This regulates gene expression and movement. It also inhibits ERK phosphorylation, PI3K–AKT signalsling, and expression downstream effectors. In addition to its roles in the development and maintenance of neural cells, it has been used to investigate the relationship between neurodevelopment and autism.

ELAVL2 (or RNA binding protein) is a protein that encodes ELAVL2. It has been implicated in several disorders, including Long QT Syndrome 3. With Episodic Ataxia. Its paralog ELAVL4, which encodes a RNA binding protein, has been associated with several genetic defects, including premature aging and spermatogenesis. Its measurement in blood and serum is made possible with an ELAVL2 immunoassay kit.

ELAVL2 promotes the growth of cells in several different cell lines. It also inhibits the apoptosis process. A study on TCam-2-cells showed that ELAVL2 overexpression led to increased proliferation of TCam-2-cells and decreased expressions of cPARP, Bax, and both cPARP. However, knockdown inhibited these effects. Moreover, ELAVL2 was decreased when AKT and ERK inhibitors were used for phosphorylation inhibition of cPARP or PLZF.

qRTPCR was used to measure Elavl2 expression from E10.5 through adult stages. The data are presented as percentages of highest samples. Error bars represent standard errors of the mean. The retina's amacrine cell amacrine cells express the ELAVL2 genes. These cells perform multiple functions and help to form the iris, cornea, as well as the brain.

Applications

The ELAVL2 marker can be used in many research applications. The SSC family conserves the protein and it is downregulated within NOA. Among its functions ELAVL2 promotes protein expression with target sequences. Recently, it was discovered ELAVL2 promotes protein synthesis in the testes. However, its exact mechanism of action remains a mystery. Currently, only three proteins have been identified as interfacing with ELAVL2.

The ELAVL2 RNA binding protein is a neural-specific RNA. It recognizes a GAAA pattern in RNA. It also recognizes several 3-UTRs. RefSeq provides information about the ELAVL2 genome. ELAVL2 is known for binding several RNAs that contain a GAAA motif.

Comparing brain tissues from mice and humans can reveal the levels of ELAVL2 expression. Normal cerebellum ELAVL3 is expressed only in the nucleus. In contrast, it is reduced in cytoplasm. ELAVL2 can co-localize with TDP43 and GFAP aggregates in cells. It is also reactive with proteins in the nuclear compartments.

Cost

The cost of the ELAVL2 marker is approximately $170. It can be purchased online or through the laboratory of your choice. ELAVL2 protein is found in cancer cells. It interacts with many proteins, including integrins. It is present in various tissues throughout the body, and is important in many types of cancer. This marker can be used in the laboratory to monitor its expression levels in tumors.