This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
ELAV-like protein 1 Antibodies
AND ELAVL1 ELISA kits, ELAV-like protein 1 Proteins
Many biological assays use antibodies to detect ELAV-like protein 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ELAV-like protein 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ELAV-like protein 1 antibodies...
Designing a Western blot for ELAV-like protein 1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ELAVL1 Western Blot GuideELAVL1 Infographic by Boster Bio
All ELAVL1 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A00736-1
100 μg/vial
Cat # A00736-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00736
100 μl
Cat # M00736
100 μl
ELAVL1 Overview
Facts about ELAV-like protein 1.
ELAV-like protein 1 (ELAVL1)
RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462). Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that aren't methylated by N6-methyladenosine (m6A), stabilizing them, boosting ESCs differentiation (By similarity).
Binds to poly-U components and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:8626503, PubMed:17632515, PubMed:18285462, PubMed:23519412, PubMed:14731398). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs.
Gene Information
| Human | |
|---|---|
| Gene Name: | ELAVL1 |
| Uniprot: | Q15717 |
| Entrez: | 1994 |
Family
| Belongs to: |
|---|
| RRM elav family |
Alternative Names
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); ELAV-like protein 1; embryonic lethal, abnormal vision, drosophila, homolog-like 1; Hu antigen R; Hua; Hu-antigen R; HuR; HURELAV1; MelG
Molecular Weight
Mass (kDA):
36.092 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.2 |
| Sequence: | 19; NC_000019.10 (7958573..8005641, complement) |
Tissue Specificity
Ubiquitous. Detected in brain, liver, thymus and muscle.
Subcellular Localizations
Cytoplasm. Nucleus. Cytoplasm, Stress granule. Translocates into the cytoplasm following phosphorylation by MAPKAPK2 (PubMed:14517288). Likewise, phosphorylation by PRKCD promotes translocation from the nucleus into the cytoplasm, where it is associated with free and cytoskeleton-bound polysomes (PubMed:18285462).Localizes to the stress granules in the presence of PLEKHN1 (By similarity).
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Cell Transformation, Neoplastic
- Inflammation
- Carcinogenesis
- Visual Impairment
- Malignant Paraganglionic Neoplasm
- Hypoxia
- Neoplasm Metastasis
Interacting Proteins
- SDCBP
- UBC
Pathways
- Translation
- Localization
- Mrna Stabilization
- Rna Interference
- Nuclear Export
- Cell Growth
- Cell Cycle
- Transport
- Cell Proliferation
- Cell Differentiation
- Angiogenesis
- Pathogenesis
- Rna Stabilization
PTMs
- Phosphorylation
- Biotinylation
- Cleavage
- Methylation
Research Areas
- Vision
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ELAVL1
bosterbio.com/bosterbio-gene-info-cards/ELAVL1
References
PMID: 8626503 by Ma W.-J., et al. Cloning and characterization of HuR, a ubiquitously expressed Elav- like protein.
PMID: 11729309 by Gallouzi I.-E., et al. Delineation of mRNA export pathways by the use of cell-permeable peptides.