ETS-related transcription factor Elf-3 (ELF3)

Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters.

Represses KRT4 promoter activity. Involved in mediating vascular inflammation.