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ELF3 Antibodies
AND ELF3 ELISA kits, ELF3 Proteins
Many biological assays use antibodies to detect ELF3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ELF3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ELF3 antibodies...
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ELF3 Infographic by Boster Bio
All ELF3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$523
Cat # M01027
100 µl
Cat # M01027
100 µl
Human, Mouse, Rat
Flow Cytometry, WB
$370
Cat # M01027-1
100 μl/vial
Cat # M01027-1
100 μl/vial
ELF3 Overview
Facts about ETS-related transcription factor Elf-3.
ETS-related transcription factor Elf-3 (ELF3)
Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters.
Represses KRT4 promoter activity. Involved in mediating vascular inflammation.
Gene Information
| Human | |
|---|---|
| Gene Name: | ELF3 |
| Uniprot: | P78545 |
| Entrez: | 1999 |
Family
| Belongs to: |
|---|
| ETS family |
Alternative Names
E74-like factor 3 (ets domain transcription factor, epithelial-specific ); E74-like factor 3; ELF3; Epithelial-restricted with serine box; epithelial-specific); Epithelium-restricted Ets protein ESX; Epithelium-specific Ets transcription factor 1; EPR1; EPR-1; ERT; ESX; ets domain transcription factor, serine box (epithelial-specific); ETS-related transcription factor Elf-3; JEN; serine box
Molecular Weight
Mass (kDA):
41.454 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q32.1 |
| Sequence: | 1; NC_000001.11 (202010583..202017183) |
Tissue Specificity
Expressed exclusively in tissues containing a high content of terminally differentiated epithelial cells including mammary gland, colon, trachea, kidney, prostate, uterus, stomach and skin.
Subcellular Localizations
Cytoplasm. Nucleus. Localizes to the cytoplasm where it has been shown to transform MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Also transiently expressed and localized to the nucleus where it induces apoptosis in non-transformed breast epithelial cells MCF-10A and MCF-12A via a transcription-dependent mechanism.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Inflammation
- Cell Transformation, Neoplastic
- Adenocarcinoma
- Malignant Paraganglionic Neoplasm
- Sarcoma
- Malignant Squamous Cell Neoplasm
- Cell Invasion
- Tissue Adhesions
Interacting Proteins
- PRKCI
Pathways
- Cell Differentiation
- Epithelial Cell Differentiation
- Circadian Rhythm
- Localization
- Cell Proliferation
- Pathogenesis
- Transport
- Cell Adhesion
- Mammary Gland Development
- Phototransduction
- Gland Development
- Regeneration
- Regulation Of Gene Expression
PTMs
- Phosphorylation
- Methylation
Research Areas
- Cancer
- Cell Cycle and Replication
- Chromatin Research
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ELF3
bosterbio.com/bosterbio-gene-info-cards/ELF3
References
PMID: 9234700 by Oettgen P., et al. Isolation and characterization of a novel epithelium-specific transcription factor, ESE-1, a member of the ets family.
PMID: 9336459 by Andreoli J.M., et al. The expression of a novel, epithelium-specific ets transcription factor is restricted to the most differentiated layers in the epidermis.