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The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. During development of the nervous system plays also a role in axon guidance.
|protein kinase superfamily|
|Sequence:||1; NC_000001.11 (22563489..22603595)|
Cell membrane; Single-pass type I membrane protein. Cell projection. Early endosome membrane. Undergoes clathrin-mediated endocytosis upon EFNA5-binding and is targeted to early endosomes.