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- Table of Contents
Ephrin type-B receptor 1 Antibodies
AND EPHB1 ELISA kits, Ephrin type-B receptor 1 Proteins
Many biological assays use antibodies to detect Ephrin type-B receptor 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ephrin type-B receptor 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ephrin type-B receptor 1 antibodies...
Designing a Western blot for Ephrin type-B receptor 1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the EPHB1 Western Blot GuideEPHB1 Infographic by Boster Bio
All EPHB1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # PB9584
100 μg/vial
Cat # PB9584
100 μg/vial
Human, Mouse, Rat
IP, WB
$370
Cat # M02811-1
100 μl/vial
Cat # M02811-1
100 μl/vial
Human, Mouse, Rat
ELISA
$540
Cat # EKC2253
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2253
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1193
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1193
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse
ELISA
$480
Cat # EKC1194
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1194
1 kit, containing one 96-well plate and all necessary reagents
EPHB1 Overview
Facts about Ephrin type-B receptor 1.
Ephrin type-B receptor 1 (EPHB1)
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands living on adjacent cells, resulting in contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is known as forward signaling while the signaling pathway downstream of the ephrin ligand is known as reverse signaling.
Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline.
Gene Information
| Human | |
|---|---|
| Gene Name: | EPHB1 |
| Uniprot: | P54762 |
| Entrez: | 2047 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
Cek6; EC 2.7.10; EC 2.7.10.1; EK6; Elk; EPH receptor B1; eph tyrosine kinase 2; EphB1; EPH-like kinase 6; ephrin type-B receptor 1; EPHT2FLJ37986; Hek6; Net; NETHek6; soluble EPHB1 variant 1; Tyrosine-protein kinase receptor EPH-2
Molecular Weight
Mass (kDA):
109.885 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q22.2 |
| Sequence: | 3; NC_000003.12 (134595264..135260467) |
Tissue Specificity
Preferentially expressed in brain.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Early endosome membrane. Cell projection, dendrite.
Diseases
- Neoplasms
- Nervousness
- Tumor Angiogenesis
- Malignant Neoplasms
- Carcinoma
- Tissue Adhesions
- Pain
- Hyperalgesia
- Carcinogenesis
- Pathologic Neovascularization
- Neuralgia
- Hyperalgesias, Mechanical
- Nerve Damage
Interacting Proteins
- GRB10
- GRB2
- GRB7
Pathways
- Angiogenesis
- Axon Guidance
- Cell Migration
- Cell Adhesion
- Cell Proliferation
- Regeneration
- Pathogenesis
- Localization
- System Development
- Vasculogenesis
- Reflex
- Cell Motility
- Cell-cell Recognition
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EPHB1
bosterbio.com/bosterbio-gene-info-cards/EPHB1
References
PMID: 8666391 by Tang X.X., et al. cDNA cloning, molecular characterization, and chromosomal localization of NET(EPHT2), a human EPH-related receptor protein- tyrosine kinase gene preferentially expressed in brain.
PMID: 9430661 by Stein E., et al. Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase.