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- Table of Contents
ERAP2 Antibodies
AND ERAP2 ELISA kits, ERAP2 Proteins
Many biological assays use antibodies to detect ERAP2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ERAP2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ERAP2 antibodies...
Designing a Western blot for ERAP2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ERAP2 Western Blot GuideERAP2 Infographic by Boster Bio
All ERAP2 Products
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Specificity
Applications
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ERAP2 Overview
Facts about Endoplasmic reticulum aminopeptidase 2.
Endoplasmic reticulum aminopeptidase 2 (ERAP2)
Aminopeptidase that plays a central role in peptide trimming, a measure required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them into the right length required for presentation on MHC class I molecules.
Preferentially hydrolyzes the basic residues Arg and Lys. .
Gene Information
| Human | |
|---|---|
| Gene Name: | ERAP2 |
| Uniprot: | Q6P179 |
| Entrez: | 64167 |
Family
| Belongs to: |
|---|
| peptidase M1 family |
Alternative Names
Aminopeptidase LRAP; EC 3.4.11; EC 3.4.11.3; endoplasmic reticulum aminopeptidase 2; ERAP2; FLJ23633; FLJ23701; FLJ23807; Leukocyte-derived arginine aminopeptidase; LRAPL-RAPEC 3.4.11.-
Molecular Weight
Mass (kDA):
110.462 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q15 |
| Sequence: | 5; NC_000005.10 (96875939..96919716) |
Tissue Specificity
Ubiquitously expressed. Highly expressed in spleen and leukocytes.
Subcellular Localizations
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Diseases
- Autoimmunity
- Malignant Neoplasms
- Spondylitis
- Ankylosing Spondylitis
- Neoplasms
- Crohn Disease
- Autoimmune Reaction
- Sclerosis
- Melanoma
- Carcinoma
- Lymphoma
- Autoimmune Diseases
- Diabetes Mellitus
Pathways
- Immune Response
- Pathogenesis
- Adaptive Immune Response
- Transport
- Transmembrane Transport
- Developmental Process
- Fertilization
- Proteolysis
- Localization
- Antigen Processing And Presentation
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ERAP2
bosterbio.com/bosterbio-gene-info-cards/ERAP2
References
PMID: 12799365 by Tanioka T., et al. Human leukocyte-derived arginine aminopeptidase. The third member of the oxytocinase subfamily of aminopeptidases.
PMID: 15691326 by Tanioka T., et al. Regulation of the human leukocyte-derived arginine aminopeptidase/endoplasmic reticulum-aminopeptidase 2 gene by interferon-gamma.